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Gastroenterology
1 Mins
1 Dec 2016

Pancreatic Cancer: The Role of Cancer-Associated Fibroblasts in Drug Metabolism

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a 5-year survival rate of only 8%. Within the USA, PDAC is expected to become…
Gastroenterology
2 Mins
1 Dec 2016

Endoscopic Mucosal Resection for Large Sessile Colonic Polyps (≥2 cm) Over a 9-Year Period: A Single-Centre Experience and Analysis of Changes Over Time in a University Teaching Hospital

Endoscopic mucosal resection (EMR) has become the standard technique for resection of large sessile and flat colonic polyps. We aimed to assess the…
Gastroenterology
2 Mins
1 Dec 2016

Unsupervised Transcriptomics-Based Clustering of Ulcerative Colitis Patients Reveals Marked Heterogeneity that Relates to Anti-Tumour Necrosis Factor Treatment Response

Heterogeneity within inflammatory bowel disease cohorts is often cited as the biggest challenge to reliably studying the clinical efficacy of therapeutics.
Gastroenterology
2 Mins
1 Dec 2016

Addition of a Solid Test Meal to Oesophageal High Resolution Manometry Improves Diagnostic Yield And Identifies Dysmotility as the Cause of Patient Symptoms

The use of oesophageal high resolution manometry (HRM) to evaluate patients who present with oesophageal symptoms in the absence of a structural lesion…
Hematology
2 Mins
28 Jul 2016

Evidence-Based Transfusion Medicine for Coagulopathy of Chronic Liver Disease

Patients with chronic liver disease variably exhibit abnormalities of coagulation related to decreased synthesis of coagulation proteins. This results in…
Hematology
2 Mins
28 Jul 2016

Management of Superficial Vein Thrombosis

Superficial vein thrombosis (SVT), indicating thrombosis of the superficial vein system, is less well-studied than deep vein thrombosis (DVT) because it…
Hematology
2 Mins
28 Jul 2016

GBT440, a Novel Sickle Haemoglobin Polymerisation Inhibitor, Increases Haemoglobin Oxygen Affinity and Results in a Rapid Improvement in Haemolysis and Anaemia

GBT440 is a novel, small molecule haemoglobin oxygen affinity modifier. In vitro data has shown that by increasing sickle haemoglobin (HbS) oxygen…
Hematology
2 Mins
28 Jul 2016

Role of the Calreticulin Gene and Its Deregulation in Myeloproliferative Neoplasms

Polycythaemia vera (PV), essential thrombocythaemia (ET), and primary myelofibrosis (PMF) are the three classical Philadelphia chromosome-negative…