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Hematology
2 Mins
2 Aug 2018

Polymorphisms in Multidrug Resistance Transporter Genes Affect the Duration of Molecular Response to Nilotinib in Chronic Myeloid Leukaemia Patients

Despite the high efficacy and improved clinical response of nilotinib in chronic myeloid leukaemia (CML), there is still a significant proportion of…
Hematology
2 Mins
2 Aug 2018

Inherited Platelet Disorders Caused by Thrombopoietin Mutation

Thrombopoietin (THPO) and the interaction with its receptor c-Mpl have a nonredundant role in platelet biogenesis and maintenance of the haematopoietic…
Hematology
1 Mins
2 Aug 2018

Bacterial Contamination of Platelet Transfusion Units Affects Platelet Haemostatic Function and Immunological Activity

Transfusion-associated bacterial infection is a major risk of platelet transfusion and can be fatal. The storage requirements of platelet concentrates…
Hematology
2 Mins
2 Aug 2018

Lenalidomide: The Gift That Keeps on Giving

First-line therapy for indolent non-Hodgkin’s lymphoma usually consists of a combination of rituximab-based chemoimmunotherapy. Historically, first-line…
Hematology
1 Mins
2 Aug 2018

A Targeted Next-Generation Sequencing-Based Diagnosis for Hereditary Anaemias

Anaemia affects 1.6 billion people worldwide, with roughly 10% of these individuals affected by rare anaemias, of which 80% are hereditary. Hereditary…
Hematology
1 Mins
2 Aug 2018

Genes and Pathways Dysregulated by Nilotinib Treatment in Bone Marrow CD34+/Lin- Cells of Patients with Chronic-Phase Chronic Myeloid Leukaemia

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. Specifically, it presents a…
Hematology
2 Mins
2 Aug 2018

A High Pretreatment Bone Marrow CD34+/CD38- Cell Burden in Patients with Myelodysplastic Syndrome is a Prognostic Factor for Disease Progression After Allogeneic Stem Cell Transplantation

Myelodysplastic syndromes (MDS) are highly heterogeneous clonal haematopoietic disorders. Allogeneic haematopoietic stem cell transplantation (HSCT)…
Hematology
2 Mins
2 Aug 2018

Longitudinal Trend Analysis of Serum Transferrin Receptor-1 Level in a Cohort of 104 Patients Affected by Non-Transfusion-Dependent Thalassaemia

The proper management of patients with non-transfusion-dependent thalassaemia (NTDT) has been a challenging mission. In fact, NTDT encompasses a great…