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Oncology

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22 Nov 2016

Cabozantinib as First-Line Therapy for Patients with Metastatic Renal Cell Carcinoma with Poor or Intermediate-Risk Characteristics

The oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI) sunitinib is a standard first-line therapy for patients with…
8 Mins
22 Nov 2016

Regorafenib in Metastatic Colorectal Cancer and Advanced Soft Tissue Sarcomas

Oncologists face multiple challenges when treating patients with cancer, especially if patients are elderly or if they experience adverse events (AEs).
8 Mins
22 Nov 2016

Editor’s Pick: Muscle Dysfunction in Childhood Cancer: Biological Mechanisms and Implications for Long-Term Survivorship

Paediatric cancer treatment has advanced significantly over the last half century to a point where >80% of all childhood cancer cases survive >5 years…
8 Mins
22 Nov 2016

The Importance of Mutational Analysis in Chronic Myeloid Leukaemia for Treatment Choice

Since their introduction in 2001, tyrosine kinase inhibitors (TKIs) targeting BCR-ABL have become the standard therapy for chronic myeloid leukaemia (CML).
9 Mins
22 Nov 2016

Modern Indications for Endoscopic Endonasal Surgery

Endoscopic endonasal surgery has become a standard procedure for functional treatment of benign pathologies. Materials and improved surgeon skills have…
10 Mins
22 Nov 2016

microRNAS in Therapy Resistance of Breast Cancer

Breast cancer is one of the deadliest cancer types worldwide and consists of several subtypes differing in their molecular characteristics; each subtype…
10 Mins
22 Nov 2016

Gastrointestinal Stromal Tumours: A Review on Genetics, Pathology, Risk Stratification, Clinical Characteristics, Investigation, and Treatment

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract, arising from the interstitial cells of…
9 Mins
22 Nov 2016

Somatic Mutations in Myelodysplastic Syndrome Patients in the Context of Allogeneic Stem Cell Transplantation

Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid disorders. Allogeneic stem cell transplantation (alloSCT) is the therapeutic approach…