Hepcidin, the Main Regulator of Iron Homeostasis, is a Marker of COVID-19 Severity and Mortality in a Cohort of Hospitalised Italian Patients
Hepcidin, the liver peptide hormone that regulates plasma iron concentration by blocking ferroportin function,4 is at the crossroad between iron metabolism and inflammation, being positively regulated by iron itself and proinflammatory cytokines,5 and may represent the link between iron deficiency and COVID-19 severity.