Dermatology

Sunscreen use may prevent UV-induced gene and epigenetic changes, helping maintain pathways linked to healthy skin, according to new molecular profiling research.

A phase IIb trial demonstrates that topical pumecitinib 3% gel significantly improves mild-to-moderate atopic dermatitis, with twice-daily dosing showing superior efficacy.

A cohort study shows mycophenolate mofetil and methotrexate reduce disease activity in juvenile localised scleroderma, with fewer adverse effects seen with MMF.

A 52-week study shows risankizumab improves both visible psoriasis and underlying vascular inflammation, with OCT revealing sustained subclinical skin changes.

A nationwide Dutch study reports treatment patterns, upstaging rates, and long-term recurrence outcomes in patients with lentigo maligna.

Acne risk rises sharply in transmasculine individuals starting testosterone and also affects transfeminine patients on estradiol. Read more.

Real-world data from Italy show high two-year drug survival and sustained disease control with bimekizumab in moderate-to-severe plaque psoriasis.

A birth cohort study reveals how genetics, environment, and hygiene shape the infant skin microbiome and its early links to atopic dermatitis.

Real-world registry data from Germany show apremilast improves psoriasis severity and quality of life, with a safety profile consistent with clinical trials.

Real-world data suggest lebrikizumab delivers sustained clinical and quality-of-life improvements in patients with moderate-to-severe atopic dermatitis.

Lower dietary antioxidant intake is linked to higher oxidative stress in rosacea, with potential implications for disease severity and clinical management.

Real-world Danish registry data show that biologic drug survival in psoriasis differs between biologic-naive and bioexperienced patients.

Adjunctive vitamin D may improve pain, healing, and inflammation in oral lichen planus, with benefits most evident during the first six weeks of treatment.

Spatial proteomics analysis shows tertiary lymphoid structures correlate with immunotherapy response and survival in Merkel cell carcinoma.

A large Mendelian randomisation study reveals that higher BMI and IBD causally increase hidradenitis suppurativa risk, providing actionable insights for dermatologists and patient counselling.

Adjunctive NB-UVB phototherapy improved disease control in chronic plaque psoriasis patients with secondary loss of response to adalimumab.

Genetic analysis shows higher BMI increases hidradenitis suppurativa risk, while smoking evidence is inconclusive. The study also supports a causal link with IBD.

Vixarelimab significantly reduced itch severity and improved skin clearance in patients with prurigo nodularis in a phase 2b randomized clinical trial.

New epidemiological data reveal long serial intervals and sustained scabies transmission in Europe, highlighting how modest prevention could curb epidemic growth.

High-throughput proteomics identifies inflammatory clusters and biomarkers associated with disease severity and treatment response in bullous pemphigoid.

A Pan-European study reports high rates of addictive behaviours among patients with chronic skin diseases, linked to poorer quality of life and key demographic factors.

Most systemic therapy-naïve patients with moderate-to-severe atopic dermatitis or psoriasis in Germany wish to escalate treatment, with clear preferences for administration route.

A large, multiethnic study reveals distinct facial microbiota patterns in adolescents with acne, identifying key bacterial species linked to acne pathology.

A new Nordic study reports no clear increase in major congenital malformations among infants exposed to topical retinoids in early pregnancy.

New research shows metabolic liver disease is linked to increased androgenetic alopecia risk, with stronger effects in women and those with unhealthy lifestyle patterns.

Fibroblasts fuel skin and systemic inflammation via a CXCL10–glycolysis axis in dermatomyositis, offering new metabolic treatment opportunities.

A phase 3 trial shows dupilumab significantly improves quality of life in omalizumab-naïve patients with chronic spontaneous urticaria.

IMCAS World Congress 2026 unites global dermatology experts to explore advances in science, aesthetics, and complication management across lasers, dermatology, and injectables.

New phase 3 trial finds ivarmacitinib ointment provides rapid, lasting relief from mild-to-moderate eczema with a favourable safety profile.

A large retrospective study shows JAK2 gene fusion occurs in both aggressive and indolent cutaneous T-cell lymphomas, offering new insight into diagnosis and targeted treatment.

Swedish study shows patients with stage IIC melanoma have poorer survival than stage IIIA, highlighting need for closer follow-up and treatment.

A phase 1b/2a trial reports that stapokibart is well tolerated and improves symptoms in children aged 6–11 years with moderate-to-severe atopic dermatitis.

A new trial finds maternal prebiotic supplementation during pregnancy does not prevent atopic dermatitis in high-risk infants at one year of age.

Lupus-like disease linked to MDS/CMML shows distinct features and poor response to standard treatment, improving with clone-directed therapy.

GLP-1 agonists are more often prescribed for hidradenitis suppurativa patients with obesity, diabetes, and other metabolic conditions.

A study shows adding oral ivermectin to permethrin improves cure rates and speeds symptom relief in children with persistent scabies, with regular follow-up over several months.

Survivors of SJS/TEN report lasting physical, psychological, and social effects, with major gaps in post-discharge care and support highlighted in a new qualitative study.

Researchers demonstrate how cross-modal imaging can noninvasively identify histologic features of skin, advancing precision in dermatologic diagnosis.

A major cohort study involving over 20 million patients found that seborrheic dermatitis was significantly associated with several epithelial barrier diseases.

A UK online trial found that daily and weekly bathing make no difference to eczema symptoms.

Recent research has demonstrated that copy-number variants play a central role in acquired ICI resistance.

Recent research has highlighted the potential of barzolvolimab, a first-in-class monoclonal antibody developed to inhibit the KIT receptor.

The relationship between physical activity and psychological wellbeing in vitiligo has gained attention in recent years.

A new study identifies active rash, interstitial lung disease, and elevated neutrophil-to-lymphocyte ratio as key predictors of in-hospital death among patients with dermatomyositis.

Recent research highlights programmed cell death mechanisms, apoptosis and necroptosis, as central to Stevens-Johnson syndrome and toxic epidermal necrolysis pathology.

Overall, the research suggests that incorporating T-cell receptor clonotype biomarkers into routine clinical assessment could significantly enhance risk stratification.

Diabetes and psoriasis together increase risk of all-cause and cancer mortality, according to a U.S. population study.

Social appearance anxiety was strongly linked to higher general anxiety, depressive symptoms, and reduced quality of life.

Discover a study showing how hydrocolloid dressing provides scar appearance comparable to daily petroleum ointment, with improved comfort and convenience for patients.

This new study examined whether stressful life factors in early childhood increase the likelihood of developing psoriasis later in life.

Crucially, most of the TFS period with the combination therapy was spent without severe toxicity, reflecting an improved quality of life.

This finding highlights that even small differences may have meaningful public health implications, given the high global prevalence of AD.

The results demonstrated a measurable improvement in acne lesion counts and significant shifts in the skin microbiota.

Many participants reported that a lack of understanding about skin cancer symptoms led to delays in seeking medical help.

A risk-stratified approach significantly enhanced skin cancer detection after organ transplantation without increasing health care burden.

In a single-centre, randomised, double-blind, sham-controlled clinical trial, 72 patients with ETR were enrolled to assess the efficacy of taVNS compared with sham stimulation.

AI tools achieve high accuracy diagnosing both STIs and anogenital dermatoses from clinical images, but more validation is needed.

Discover a study revealing how the seboselective 1726-nm laser delivers safe, long-lasting acne treatment results with improved skin clarity and confidence.

Discover a study on oral povorcitinib for vitiligo, showing significant repigmentation and safety in patients with extensive nonsegmental vitiligo.

A recent post hoc analysis used data from a Phase III trial of the new interleukin (IL)-17A inhibitor, vunakizumab, to explore predictors of early response.

Skin-to-skin contact in hospital helps very preterm infants develop stronger brain pathways for stress and emotions.

The International Psoriasis Council (IPC) has outlined clear criteria to help clinicians determine when systemic therapy should be prioritised.

Discover a study showing how neoadjuvant immunotherapy with tiragolumab and atezolizumab improves response rates and safety in high-risk Stage III melanoma.

In a randomised, placebo-controlled trial, researchers evaluated VC-H1, a hibiscus enzyme extract, as an oral plant-based collagen alternative for photoaged skin.

The study demonstrated that [99mTc]Tc-Tilmanocept could detect secondary lesions in patients with melanoma undergoing ICI treatment.

Discover a study exploring how hyaluronic acid and amino acids work together to accelerate healing in hard-to-heal wounds.

Oral isotretinoin remains the most effective therapy, although its precise mechanism is not fully understood.

Patients receiving once-daily upadacitinib 30 mg achieved significantly greater reductions in abscesses and inflammatory nodules compared with historical placebo rates.

The results revealed that patients with AD displayed a less favourable cardiovascular risk profile.

Beyond disease associations, CPAP mask-related skin complications such as dermatitis may arise due to friction, pressure, moisture, or sensitivity to mask materials.

A key finding was that patients treated at specialist centres experienced a significantly shorter delay in switching from immunosuppressants to advanced systemic therapies.

In Cohort 1, data from 787 participants revealed that current smokers, who comprised 53.9% of the group, were more likely to present with severe disease.

Discover a study linking select autoimmune diseases with increased risks of melanoma and non-melanoma skin cancers, highlighting the need for closer surveillance.

Importantly, patients with clear margins from excisional biopsy alone, who did not undergo wide excision, showed no recurrence after a median of more than eight years.

Ultraviolet B (UVB) phototherapy is the traditional non-pharmacological approach, promoting repigmentation by stimulating melanin production.

Global prevalence of HS, estimated between 0.67–1.46%, surpassed previous estimates, with substantial global variations.

While medical treatments remain the cornerstone of care, skincare is increasingly being recognised as a valuable adjunct to therapy.

Learn how AI-driven skincare improved acne and quality of life more effectively than self-chosen products in recent clinical trial.

Discover a study evaluating combined dye and alexandrite laser therapy, offering promising results for improving outcomes in patients with papulopustular rosacea.

The study found that almost 8% of individuals aged two years and above had asthma, while more than half (52.3%) reported allergy symptoms.

Objective biometric measures showed improvement in both groups, but the combination therapy produced significantly greater benefits.

Clinical examination is limited by visual similarity between benign and malignant lesions and imperfect diagnostic accuracy.

Delgocitinib ointment could be an effective and safe option for patients with face or neck atopic dermatitis (AD) who are concerned about the side effects of topical steroids or tacrolimus

Biomarker analyses continue to provide insights but have not yet established clear rules for patient selection.

By Month 6 (M6), 50–60% achieved at least a one-point improvement across validated HS severity measures.

Discover a study comparing intralesional triamcinolone and methotrexate for alopecia areata, revealing superior regrowth and patient satisfaction with triamcinolone.

This study evaluated the psychometric performance and interpretability of HiSQOL using data from two multinational Phase III trials of bimekizumab in moderate-to-severe HS.

A recent study evaluated a novel 2% salicylic acid gel enriched with hydrating and soothing agents, aiming to balance acne treatment with skin barrier repair.

Apremilast shows sustained 52-week efficacy and safety in children with moderate to severe plaque psoriasis.

Discover how fewer melanoma cases with more severe features were seen during COVID, highlighting need for robust skin cancer pathways.

Biologic switching in psoriasis improves skin outcomes but requires careful infection monitoring, finds major review.

Patients with hidradenitis suppurativa face a significantly higher risk of developing new-onset depression and anxiety, according to a large Danish population-based study.

Daily moisturising may prevent infant eczema, even in low-risk babies, offering a practical approach for early skin care.

Discover a study highlighting the improved effectiveness of combining light-based therapy with tranexamic acid for treating facial redness.

Results showed the secretome-HA sponge improved skin hydration, reduced transepidermal water loss, increased skin elasticity.

Results from the 12-month double-blind, placebo-controlled trial revealed that the vaccinated group consistently experienced greater reductions in AK lesions than the control group.

The study examined flare patterns reported in 2022 and correlated them with patient-reported severity measures recorded in 2023.

These vaccines work by activating the immune system to recognise and attack tumour cells, while also creating immune memory for long-term protection.

Results demonstrated a clear association between elevated emotional distress and poorer TIL therapy outcomes.

Gene expression analysis also revealed that increased Myc-related gene expression correlated with poorer outcomes.

Discover a study highlighting how tapinarof cream 1% delivers rapid, clinically significant itch relief in children and adults with atopic dermatitis.

Both treatments resulted in significant improvement in inflammatory acne lesions; however, IPL yielded better overall outcomes.

This post hoc analysis included data from 25 randomised clinical trials, assessing over five years of IXE exposure in patients with psoriasis.

As HS remains underdiagnosed and undertreated, findings such as these could help support more informed, patient-specific therapeutic decisions moving forward.

A recent study has demonstrated that deep learning models can enhance diagnostic accuracy in differentiating these pigmented lesions.

Discover a study revealing how vitamin C supports skin regeneration by promoting keratinocyte proliferation through epigenetic DNA demethylation.

The study highlights how HR pathway alterations, which affect roughly a fifth to a third of melanomas, may offer an opportunity for targeted treatment.

VISIBLE Cohort B represents a landmark study in psoriasis research, being the only scalp psoriasis trial exclusively including individuals with skin of colour.

Researchers developed a self-injection assistance device, allowing patients to administer triamcinolone themselves under medical guidance.

Given dupilumab’s well-documented benefits in controlling moderate to severe AD, clinicians are advised to weigh this potential risk carefully against its therapeutic advantages.

The bidirectional relationship between psoriasis and MetS was supported by evidence showing that metabolic disturbances can also exacerbate psoriasis symptoms.

Discover a study where two investigators, using new TikTok accounts registered as 13-year-olds, collected and analysed the videos through the platform’s “For You” tab.

Following surgery, 97.2% of patients experienced a reduction in psoriasis severity to mild levels or complete resolution.

The findings indicate that children with HS are significantly more likely to suffer from a range of both physical and mental health conditions.

The model integrates four key types of imagery: total-body photographs, standard clinical photos, dermoscopic close-ups, and dermatopathology slides.

Compared to patients from the highest SES quintile, those in the lowest quintile had over three times the odds of being diagnosed with hidradenitis suppurativa.

A new global observational study has revealed a continued rise in skin cancer burden among older populations, particularly in high-income countries.

The results revealed that central adiposity, fat concentrated around the waist and abdomen, had the strongest link to psoriasis.

The findings highlight that abobotulinum toxin A and prabotulinum toxin A demonstrated the quickest onset of action.

In this study, researchers examined three international cohorts of patients with moderate-to-severe psoriasis undergoing biologic therapy.

Pure atopic dermatitis patients had a significantly higher prevalence of cardiovascular disease compared to those with atopic comorbidities

Young adults (18–29 years) had the highest UV exposure and sunburn rates, and were least likely to use protective clothing.

Interestingly, UVB exposure and topical application of cis-UCA led to changes in the skin’s microbial composition.

Mental health issues such as anxiety and depression are common comorbidities in people with atopic dermatitis.

The results demonstrated significantly greater improvement in the ivarmacitinib groups compared to placebo.

Discover a study that evaluated the effectiveness of hyperbaric oxygen therapy for radiation-induced dermatitis.

A study has shed new light on a novel approach to managing acne vulgaris, highlighting the efficacy of an oral nutraceutical.

Safety concerns surrounding certain therapies in children often lead to suboptimal management of atopic dermatitis.

Restoring the skin barrier is key in managing and potentially preventing atopic dermatitis.

An increasingly studied adjunctive therapy is Hyaluronic Acid, known for its hydrating, regenerative, and anti-inflammatory properties.

Beyond clinical outcomes, the simultaneous approach offered additional benefits: reduced overall treatment time and higher patient satisfaction.

This study underlines the urgent need for cost-conscious strategies in the management of plaque psoriasis.

Results revealed that the group using partially myristoylated carboxymethyl chitosan emulsion experienced a significantly greater reduction in EASI scores.

Discover a study with has highlighted the potential of a novel silk elastin-based sponge as an effective wound treatment.

A recent clinical trial has compared the effectiveness of IL-17 and IL-23 biologics in treating moderate to severe plaque psoriasis.

Discover a recent study that indicates that autonomous total body photography could be a valuable tool in dermatological settings.

The study’s findings suggest that targeting the epidermal innate immune system could improve long-term treatment outcomes.

Recent research has highlighted the role of neutrophil extracellular traps in inflammatory diseases.

The study assessed the risk of hospitalisation for serious infections based on different categories of systemic medications.

The results indicated that 3D total-body photography reduced the number of melanoma excisions compared to controls.

From a therapeutic perspective, these findings advocate for a more tailored approach to treatment.

Spesolimab, a monoclonal antibody targeting the interleukin (IL)-36 receptor, has been approved as the first GPP-specific therapy.

The findings of this study suggest that both 70% and 100% TCA achieve similar overall results.

Results suggest that standard HPV vaccination may offer a novel approach to actinic keratosis management.