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6 Mins
20 Oct 2022

Clinical Efficacy and Outcomes of Remibrutinib (LOU064) in Patients with Chronic Spontaneous Urticaria Inadequately Controlled with H1-Antihistamines: Findings from a Phase IIb Study

Chronic spontaneous urticaria (CSU) is characterised by the spontaneous occurrence of wheals (hives) and/or angioedema for ≥6 weeks.1 CSU can persist for several years and is associated with severe pruritus. Skin mast cell activation in CSU occurs via Type I autoallergy driven by IgE to autoallergens, and a Type IIb autoimmune response due to mast cell-targeted autoantibodies against IgE or high-affinity IgE receptor.
5 Mins
20 Oct 2022

Secukinumab in Moderate-to-Severe Hidradenitis Suppurativa: Primary Endpoint Analysis from the SUNSHINE and SUNRISE Phase III Trials

The primary endpoint analyses from the SUNSHINE and SUNRISE Phase III trials of secukinumab in moderate-to-severe hidradenitis suppurativa (HS) were featured in an oral presentation as part of the late-breaking news session at the 31st annual European Academy of Dermatology and Venereology (EADV) congress. Known collectively as the SUNNY trials, the SUNSHINE and SUNRISE studies represent the largest Phase III trials conducted in HS to date.
5 Mins
4 Jul 2022

Editor's Pick: Pemphigus Vulgaris and Pemphigus Foliaceus: A Single-Centre Comparative Study in Rabat, Morocco

Pemphigus is a group of rare autoimmune blistering diseases affecting the skin and mucous membranes. Pemphigus foliaceus (PF)…
9 Mins
16 Jun 2022

Beyond Aesthetics: Hyaluronic Acid Fillers as a Therapeutic Treatment

Any filler injection requires a bespoke treatment approach and a thorough anatomy knowledge to minimise procedural risks and achieve…
10 Mins
30 May 2022

A Retrospective Database Cohort Study Evaluating the Association Between Immune Suppressive Therapy and the Development of Cancer in Patients with Atopic Dermatitis Within UK Primary Care

Atopic dermatitis (AD) is the most common inflammatory skin condition, affecting 11–20% of children and 5–10% of adults…
7 Mins
9 May 2022

Trichotillomania with Giant Gastric Trichobezoar in a Female Child: A Case Report

Trichotillomania is defined by the Diagnostics and Statistic Manual of Mental Disorders (DSM-5) as an individual repetitively pulling…
5 Mins
2 May 2022

Varicella Zoster Reactivation Following mRNA Vaccination: Two Case Reports and a Review of Cutaneous Adverse Events of COVID-19 Vaccines

Varicella Zoster reactivation and cutaneous reaction as a mRNA vaccine side effect following COVID 19 vaccination…
4 Mins
28 Apr 2022

Case Report of Epstein–Barr Virus-Induced Autoimmune Vitiligo in Nigeria

Vitiligo is an acquired skin depigmenting disorder resulting from melanocytes loss in the epidermis, associated with an autoimmune aetiopathophysiology. However, there are limited data about the association between vitiligo and Epstein–Barr virus (EBV).