Dermatology

As part of the 31st European Academy of Dermatology and Venereology (EADV) Annual Congress held in Milan, Italy, and online, 7th–10th September 2022, five poster presentations outlined results from the Phase IIb study of remibrutinib (LOU064) in patients with chronic spontaneous urticaria inadequately controlled with H1-antihistamines.

This year’s European Organisation for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Tumours Group (CLTG) Annual Meeting was held in Madrid, Spain. Presentations covered a broad range of topics in the field of cutaneous lymphomas, from molecular mechanisms, through diagnostics and prediction of prognosis, to skin-directed and targeted therapies, combination therapies, and patient-reported outcomes.

Sun exposure can lead to tanning, but also to skin damage due to the actions of ultraviolet A and B, visible light, and infrared radiation. One result of sun exposure is field cancerisation (FC), the precursor to actinic keratosis (AK), which in turn is a risk factor for, most notably, squamous cell carcinoma.

Chronic spontaneous urticaria (CSU) is characterised by the spontaneous occurrence of wheals (hives) and/or angioedema for ≥6 weeks.1 CSU can persist for several years and is associated with severe pruritus. Skin mast cell activation in CSU occurs via Type I autoallergy driven by IgE to autoallergens, and a Type IIb autoimmune response due to mast cell-targeted autoantibodies against IgE or high-affinity IgE receptor.

The primary endpoint analyses from the SUNSHINE and SUNRISE Phase III trials of secukinumab in moderate-to-severe hidradenitis suppurativa (HS) were featured in an oral presentation as part of the late-breaking news session at the 31st annual European Academy of Dermatology and Venereology (EADV) congress. Known collectively as the SUNNY trials, the SUNSHINE and SUNRISE studies represent the largest Phase III trials conducted in HS to date.

Pemphigus is a group of rare autoimmune blistering diseases affecting the skin and mucous membranes. Pemphigus foliaceus (PF)…

Any filler injection requires a bespoke treatment approach and a thorough anatomy knowledge to minimise procedural risks and achieve…

Atopic dermatitis (AD) is the most common inflammatory skin condition, affecting 11–20% of children and 5–10% of adults…

Trichotillomania is defined by the Diagnostics and Statistic Manual of Mental Disorders (DSM-5) as an individual repetitively pulling…

Varicella Zoster reactivation and cutaneous reaction as a mRNA vaccine side effect following COVID 19 vaccination…

Vitiligo is an acquired skin depigmenting disorder resulting from melanocytes loss in the epidermis, associated with an autoimmune aetiopathophysiology. However, there are limited data about the association between vitiligo and Epstein–Barr virus (EBV).

Drug-induced photosensitivity is an adverse cutaneous reaction caused by a simultaneous exposure to potentially photosensitising drugs (via topical application or parenteral administration) and ultraviolet (UV) radiation or visible light.

The solar spectrum is composed of various wavelengths of electromagnetic radiation that can penetrate the skin to different levels: the longer…

Currently, the exact mechanism underlying EMPD is unknown, but two widely known theories exist, namely the epidermotropic and transformation theories.

A case of a 25-year-old White female left with residual bone deformity after surgical correction of craniosynostosis during childhood…

The latest research on autoimmune skin disease has studied the efficacy and safety characterisation of guselkumab (GUS), a human monoclonal…

Strober began by summarising his opinion on the key characteristics of anti-IL-23 therapies that support their efficacy for inducing…

Dermatophytes are the keratinophilic moulds living on the superficial layer of human and animal skin and are transmitted by direct and…

A number of misconceptions prevail in nail melanoma. This short essay tries to clarify some of these issues.

Interviewing Peter Lio, Clinical Assistant Professor of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine

The latest international guidelines on urticaria were published in September as a joint initiative from the European Academy of…

Recent years have witnessed significant advances in the understanding of facial anatomy. Extensive studies have uncovered the arrangement of soft-tissue layers underlying the skin and their mobility during expression. Meanwhile, increasing awareness of the facial vascular network has laid the foundation for lower risk cosmetic procedures.

An interview with Roxana Daneshjou, Clinical Scholar of Dermatology, Stanford University, California, USA.

Tuberous sclerosis complex (TSC) is an autosomal dominant hereditary disease with hamartomatous growths in multiple organs due to…

Psoriasis is a chronic inflammatory skin condition that impacts patients’ quality of life and has large economic consequences…

Richard B. Warren highlighted Psoriasis Symptoms and Impacts Measure (P-SIM) responses from the Phase III BE VIVID trial in patients…

In the late-breaking research sessions, Reich presented BE RADIANT, the first Phase III trial to compare inhibition of IL-17A and IL-17F…

This Janssen-sponsored live satellite symposium, entitled ‘Where do we begin? The key role of the IL-23 pathway in psoriasis and psoriatic…

Pioneering global best practices in atopic dermatitis (AD) and implementing them in the clinic are important steps towards optimising patient care…

Botulinum neurotoxins (BoNTs) are derived from Clostridium botulinum, a gram-positive anaerobe. While there are seven subtypes of BoNT (A to G), only A…

The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen and the subsequent coronavirus disease (COVID-19) mainly affect the lung…

Eczematous dermatitis (or eczema) includes AD, CD, and DD. This inflammatory skin reaction presents as erythema, vesicles, desquamation…

Atopic dermatitis (AD), sometimes referred to as ‘atopic eczema’, is a common, chronic, pruritic, Type II inflammatory skin disease which is associated…

At birth, the skin of the newborn suddenly comes into contact with the extrauterine world: a dry and aerobic environment.1 Newborn skin is 40–60%…

Syphilis is a chronic bacterial infection caused by Treponema pallidum subspecies pallidum, known by clinicians for hundreds of years and with more than 5 million new cases diagnosed every year worldwide…

The indicative scaly, erythematous plaques of plaque psoriasis arise because of abnormal interactions between immune system cells and epidermal…

Terrestrial solar UVR consists of UVA (320–400 nm) and UVB (280–320 nm; typically around 295–320nm because of attenuation by the ozone…

Psoriasis, a chronic systemic inflammatory disease with skin manifestations, can be an impediment to daily life. Accordingly…

Prof Reich began by highlighting how insights into the pathophysiology of psoriasis have led to the development and expansion of cytokine-targeted…

The VOYAGE 1 trial1 was a placebo- and active-controlled Phase III study to evaluate long-term efficacy and safety of the IL-23p19 inhibitor guselkumab…

Psoriasis is a Th17-driven disease, with both IL-17A and IL-17F playing a pivotal role in its pathogenesis.2,3 BKZ is a monoclonal IgG1 antibody…

Chronic urticaria (CU) is one of the most commonly diagnosed skin conditions. CU is characterised by the presence of recurrent wheals and/or angioedema…

Recessive dystrophic epidermolysis bullosa (RDEB) and junctional EB (JEB) are inherited disorders characterised by fragility and blistering of epithelial…

With the recent advancements of biologic therapies that block IL-23, there is increasing need for analysis of which biologics are most efficacious…

Stevens–Johnson syndrome and toxic epidermal necrolysis are well-known severe cutaneous adverse reactions, with >100 medications previously implicated…

Ungual psoriasis and onychomycosis are common nail diseases. Despite their different aetiology and course, surprisingly they have much in common.

This clinical dermatology report examines six short case studies of patients diagnosed with acne vulgaris, actinic keratosis (AK), and atopic dermatitis (AD)…

An enhanced understanding of real-world CL Gel usage could help improve the management of patients with MF-CTCL…

Pemphigoid gestationis (PG) is a rare pruritic autoimmune blistering skin disease associated with pregnancy and is classified as a pregnancy-specific…

“Psoriasis isn’t just a skin disease”: depression, anxiety, and alexithymia are common in people living with the condition, as are low self-esteem…

MF-CTCL is a rare type of cutaneous non-Hodgkin’s lymphoma where uncontrolled growth of the pathological skin-homing T-lymphocytes results first in skin…

Cumulative or excessive solar exposure is detrimental to skin health.1 Furthermore, certain population groups require extra care…

Sebaceous carcinoma is a rare and very aggressive malignant skin cancer of the sebaceous gland. While sebaceous glands are present all over the body…

Urticaria is a common mast cell-driven disease characterised by wheals and/or angioedema (), defined as chronic…

Skin diseases such as psoriasis can profoundly influence a patient’s self-image, self-esteem, and sense of wellbeing. The chronic nature of the disease…

Advances in the treatment of moderate-to-severe psoriasis have accelerated considerably in the last 30 years. Prof Piaserico provided an overview of the…

Psoriasis is a chronic, relapsing inflammatory skin disease, characterised in most cases by sharply demarcated, erythematous, pruritic plaques covered…

IL-23 plays a key regulatory role in the pathogenesis of plaque psoriasis and medications targeting IL-23 have been shown to be effective for people with…

Development of psoriasis occurs due to interactions with epidermal keratinocytes and immune-system cells including T-lymphocytes, antigen-presenting…

Psoriasis is associated with high morbidity, causing problems in daily life such as itching and scaling, even for patients with less-severe disease…

Allergies represent a significant, rising health concern. Recent figures indicate that 150 million Europeans experience chronic allergic disease…

The symposium “IL-23 Inhibition: From Pathophysiological Jungle to Clinical Clearance” took place during the 2019 annual European Academy of Dermatology…

Guselkumab was the first monoclonal antibody targeting the p19 subunit of IL-23 (IL-23p19) to be approved for the treatment of psoriasis.

Prof Augustin opened the symposium by underlining how the management of patients with moderate-to-severe atopic dermatitis (AD) has become more dynamic…

Psoriasis and AD are chronic, systemic inflammatory diseases of the skin characterised by upregulation of proinflammatory cytokines…

Acne is the most common skin condition in the USA, affecting over half of its population.1 It is an inflammatory skin disease that predominantly…

Atopic dermatitis (AD) is one of the most common and debilitating chronic inflammatory skin diseases, often greatly affecting physical, economical…

The objectives of this symposium were to understand the importance of planning treatment addressing the specific needs of women living…

Type 2 immunity evolved from a dialogue between the immune system and microbes. This form of immunity confers protection against bacteria, viruses…

Hidradenitis suppurativa, or acne inversa, is a chronic, recurrent inflammatory disease of the skin and subcutaneous tissue characterised by painful…

The main objective of this manuscript is to offer an organised and updated review of the clinical features and current treatment options for paediatric serum sickness-like reaction.

Prof Schaller posed the question “what makes rosacea so special?” and explained that the manifestations of rosacea are very varied, including papules…

Psoriasis is a common, chronic, immune-mediated skin disease affecting approximately 2–3% of the global population…

Psoriasis occurs more frequently alongside other IMID, indicating common pathogenetic pathways. Many of these IMID show familial accumulation…

The fumarates, monoethyl fumarate (MEF) and dimethyl fumarate (DMF), are potent ester derivatives of fumaric acid. Fumaric acid esters (FAE)…

This sponsored symposium took place on 12th June 2019 in Milan, Italy, as part of the 24th World Congress of Dermatology (WCD), 2019

This symposium took place on 13th June 2019, as part of the World Congress of Dermatology (WCD) symposium in Milan, Italy

Sarcoidosis is a multisystem disease, of unknown aetiology, which can involve any organ of the body, even if it more frequently affects the lymph nodes…

Prof Elke de Jong focussed her presentation on data from randomised clinical trials (RCT) and real-world evidence (RWE) from psoriasis patient registries.

Dermatologists frequently see psoriasis patients for whom the most troublesome symptoms are not the constant physical discomfort…

Hypertrophic scar (HTS) is a dermal form of fibroproliferative disease that develops after deep burns, skin injuries, and surgical wounds.  HTS is defined…

The purpose of this paper is to explore heat shock protein 90-alpha (Hsp90α)’s role as a potential driver of wound healing and as a possible future…

Affecting up to 11.4% of the population worldwide, psoriasis is one of the most common chronic autoinflammatory diseases.

Chronic urticaria is one of the most commonly diagnosed dermatoses. Following diagnosis, correct identification and proper treatment significantly reduces disease activity, thereby improving the patient’s quality of life.

The goal of this programme is to support dermatologists to improve the management of patients with moderate-to-severe AD and bring together clinicians…

This presentation by Dr Weisenseel considered the role of fumaric acid esters (FAE) in plaque psoriasis.

The rising incidence of CSCC presents a major challenge for healthcare systems and the frequency and impact of progression to advanced disease is…

Following a brief introduction by Prof Lambert, the symposium started with an in-depth review of the current unmet needs in the clinical management of…

Common variable immunodeficiency (CVID) is a predominantly antibody deficiency and is one of the most common primary…

The main objectives of the symposium were to review recent evidence on what difference targeting Psoriasis Area Severity Index (PASI) 90 or 100 and…

The importance of discussions around the management of women of childbearing age with psoriasis, an issue that has been largely neglected for many years…

Prof Reich outlined the new understanding of psoriasis pathogenesis, with IL-23 rather than IL-12 considered the pivotal cytokine pathway. This…

This symposium took place at the 27th European Academy of Dermatology and Venereology (EADV) Congress. The session examined the latest data for…

This symposium, which took place during the 2018 meeting of the European Academy of Dermatology and Venereology (EADV) in Paris, France, provided…

Guselkumab is a monoclonal antibody targeting IL-23 that is approved for the treatment of patients with moderate-to-severe plaque psoriasis. Two of…

Plaque psoriasis is an autoimmune condition characterised by the development of red, dry, scaly skin lesions that cause irritation and pain for patients…

Psoriasis is a chronic autoimmune skin disease with significant physical and psychiatric comorbidities and affects 2–3% of people worldwide.

The objective of this study was to conduct a systematic review of the available evidence on the treatment of herpes simplex labialis with U.S. Food and Drug Administration (FDA)-approved topical antibiotics.

Chronic urticaria (CU) is characterised by intense recurrent itch, wheals, and/or angioedema, persisting for >6 weeks. CU can be subdivided into chronic…

Psoriasis is a common skin disease with various cutaneous manifestations and is classified into two clinical groups: non-pustular and pustular.

Prof Boehncke opened the symposium and highlighted the changing landscape of psoriasis management. On behalf of Prof Mrowietz, who was unable to attend…

Substantial developments over the last decade have advanced our knowledge and understanding of psoriasis, from both a basic scientific and clinical…

This article reviews new data presented at the recent European Society for Photodynamic Therapy (Euro-PDT) Annual Congress 2018. The role of topical…

This publication covers the first session of Almirall’s 11th Skin Academy meeting in Barcelona, Spain. This year, the meeting theme was ‘The Science of…

The beginning of warmer weather brings optimism for most people as they emerge from winter. However, for those of us living with a highly stigmatised…

Social media platforms, such as Instagram, are particularly powerful when it comes to empowering psoriasis patients and reducing social stigma.

Prof Reich welcomed delegates to the satellite symposium and explained that the aims of the meeting were to introduce the clinical role of targeted…

Registries provide very high-quality data on the persistence of different therapies in the real world and can be used to compare and guide therapeutic…

The satellite symposium comprised two short presentations aimed at providing an overview of the rationale for the use of interleukin (IL)-23 inhibition…

Previously considered as just a skin condition, psoriasis has come to be regarded as a complex, systemic inflammatory disorder that affects multiple…

Urticaria is a common skin condition that, though rarely fatal, can seriously impair a patient’s quality of life. Urticaria is caused by…

This article presents a case of longitudinal melanonychia in a teenager with atypical signs and a good prognosis.

This year, World Leprosy Day falls on Sunday 28th January. The occasion has been observed since 1954 and aims to raise awareness, providing more people…

Prof Girolomoni provided an overview of psoriasis, considering how patients are frequently affected by other comorbidities.

The oral session consisted of a talk on the 2-year efficacy and safety of guselkumab in the treatment of moderate-to-severe psoriasis from the Phase III VOYAGE 1 trial.

Prof Costanzo welcomed attendees to the symposium and outlined the agenda before explaining the autoimmune pathophysiology that underlies psoriasis.

Some types of chronic urticaria (CU) are associated with autoreactive immunoglobulin (Ig)E, as well as IgG. In the syndrome of autoimmune thyroid disease…

MY TREATMENT with isotretinoin was a long time coming. Having suffered for many years with severe acne, and with antibiotics only making a small dent in…

This symposium is focused on topical therapies in the treatment of psoriasis and the unmet clinical and patient quality of life needs.

Dermatologists today have more tools than ever at their disposal for managing psoriasis, including newer-generation biologics, which target molecular…

Psoriasis is a chronic inflammatory disease that is associated with a reduction in quality of life (QoL) and professional work productivity.

Hidradenitis suppurativa is a debilitating, chronic, relapsing inflammatory condition associated with the development of painful nodules.

In children, chronic urticaria is substantially less common than acute urticaria but is associated with a larger decrease in quality of life. Read to find out more.

Skin, with its many biological functions, has a unique aesthetic value and determines the self-image and psyche of the person in terms of how they think…

Hidradenitis suppurativa is an inflammatory skin condition of the follicular pilosebaceous unit that primarily affects flexural areas where apocrine…

The use of dermoscopy in general dermatological practice has recently increased.

Schnitzler syndrome is a rare acquired autoinflammatory disorder that is characterised by recurrent fevers, bone or joint pains, urticarial rash, and…

The mind–skin interaction has been progressively clarified by recent research that has focussed on psychoneuroimmunology.