Dermatology

To discuss how biologics have disrupted clinical management of atopic dermatitis, and how tralokinumab fits into this paradigm, the EMJ sat…

Hair loss is a common problem in clinical dermatology, with many aetiologies including but not limited to androgenetic alopecia…

Hyaluronan, or hyaluronic acid (HA), is an extracellular matrix glycosaminoglycan distributed throughout the body, primarily found in…

Congenital ichthyosis represents keratinisation disorders characterised by abnormal skin scaling across the entire body, leading to a red…

Basal cell carcinoma (BCC) is a heterogeneous malignant neoplasm and can cause great morbidity as most occur in highly visible areas of…

Now, as a practicing physician, I have no insecurities about being a woman in business, because in my training, I would be in a room with hundreds of women at the Women’s Dermatological Society.

Hyperpigmentation disorders, a group of common skin conditions characterised by darkened patches due to excess melanin production, affect…

Scalp hair is often regarded as a symbol of beauty and vitality across many cultures. Consequently, the loss of hair can significantly…

Dermatitis artefacta (DA), also known as artefactual skin disease, is a rare psychocutaneous disorder characterised by…

Severe cutaneous adverse drug reactions (SCAR) are a group of rare but potentially life-threatening conditions that can occur in response…

JAK INHIBITORS have changed dermatology, and will continue to change dermatology in ways that no other class of drugs has…

The aim of our work was to underline that surgery can be applied as a first-line treatment. This was also the shared starting assumption…

Melanoma of the skin is a common type of cancer that primarily affects younger patients. In Stage III melanoma, which does not involve…

We agree that the topic of treatment of penile lichen sclerosus in boys is important, and needs more attention in clinical research and…

Psoriasis symptoms can be not only uncomfortable, irritating, and painful, but can also impact several aspects of a patients’ daily life…

Due to the clinical heterogenicity of HS, assessment of disease severity is complex, and over 20 different outcome measures have…

Vitiligo is an autoimmune skin disorder that causes depigmentation of the skin and/or leukotrichia of the hair, resulting from the…

Psoriatic disease is a chronic, inflammatory immune condition affecting more than 40 million individuals worldwide…

This review article aims to provide an overview of platelet-rich plasma’s applications and evidence over the past 5 years in randomised…

This review provides a systematic approach for dermatologists to use in order to accurately diagnose hair loss disorders…

During this symposium, global experts in dermatology gave a series of lectures focused on skin treatments and their benefits for patients…

Mycosis fungoides is the most common form of cutaneous T cell lymphoma. In this article, the authors describe a case of a 53-year-old…

Vitiligo is an autoimmune disorder characterised by the loss of melanocytes, resulting in white, depigmented cutaneous macules…

COVID-19 and cosmetic skin-fillers are two prevalent topics of today’s medicine, yet their interaction is not sufficiently studied. This…

Morphoea causes skin and subcutaneous tissue fibrosis, and can sometimes involve the fascia, muscle, or bone. Sclerosis usually begins as…

Parry–Romberg syndrome (PRS) is a rare neurocutaneous condition that can affect the skin, subcutaneous fat, muscle, and bone on one side…

This review of the ‘Elevating Aesthetics’ symposium held at the International Master Course on Aging Science (IMCAS) 2023 shares insights…

I was always interested in biology and science. As a child, I loved identifying wild flowers and this is not all that dissimilar to…

There were actually two reasons. When I was about 4 years old, I was given a bird book by my parents and I memorised every bird…

Cutaneous squamous cell carcinoma (SCC) contributes to 20% of non-melanoma skin cancers and early diagnosis is vital to reducing…

Psoriasis is a chronic inflammatory skin disorder affecting approximately 60 million people worldwide. The condition presents with rapid hyperproliferation and dysregulated differentiation of epidermal keratinocytes, manifesting clinically as salmon pink plaques with overlying silvery-white scale.

As part of the 31st European Academy of Dermatology and Venereology (EADV) Annual Congress held in Milan, Italy, and online, 7th–10th September 2022, five poster presentations outlined results from the Phase IIb study of remibrutinib (LOU064) in patients with chronic spontaneous urticaria inadequately controlled with H1-antihistamines.

This year’s European Organisation for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Tumours Group (CLTG) Annual Meeting was held in Madrid, Spain. Presentations covered a broad range of topics in the field of cutaneous lymphomas, from molecular mechanisms, through diagnostics and prediction of prognosis, to skin-directed and targeted therapies, combination therapies, and patient-reported outcomes.

Sun exposure can lead to tanning, but also to skin damage due to the actions of ultraviolet A and B, visible light, and infrared radiation. One result of sun exposure is field cancerisation (FC), the precursor to actinic keratosis (AK), which in turn is a risk factor for, most notably, squamous cell carcinoma.

Chronic spontaneous urticaria (CSU) is characterised by the spontaneous occurrence of wheals (hives) and/or angioedema for ≥6 weeks.1 CSU can persist for several years and is associated with severe pruritus. Skin mast cell activation in CSU occurs via Type I autoallergy driven by IgE to autoallergens, and a Type IIb autoimmune response due to mast cell-targeted autoantibodies against IgE or high-affinity IgE receptor.

The primary endpoint analyses from the SUNSHINE and SUNRISE Phase III trials of secukinumab in moderate-to-severe hidradenitis suppurativa (HS) were featured in an oral presentation as part of the late-breaking news session at the 31st annual European Academy of Dermatology and Venereology (EADV) congress. Known collectively as the SUNNY trials, the SUNSHINE and SUNRISE studies represent the largest Phase III trials conducted in HS to date.

Pemphigus is a group of rare autoimmune blistering diseases affecting the skin and mucous membranes. Pemphigus foliaceus (PF)…

Any filler injection requires a bespoke treatment approach and a thorough anatomy knowledge to minimise procedural risks and achieve…

Atopic dermatitis (AD) is the most common inflammatory skin condition, affecting 11–20% of children and 5–10% of adults…

Trichotillomania is defined by the Diagnostics and Statistic Manual of Mental Disorders (DSM-5) as an individual repetitively pulling…

Varicella Zoster reactivation and cutaneous reaction as a mRNA vaccine side effect following COVID 19 vaccination…

Vitiligo is an acquired skin depigmenting disorder resulting from melanocytes loss in the epidermis, associated with an autoimmune aetiopathophysiology. However, there are limited data about the association between vitiligo and Epstein–Barr virus (EBV).

Drug-induced photosensitivity is an adverse cutaneous reaction caused by a simultaneous exposure to potentially photosensitising drugs (via topical application or parenteral administration) and ultraviolet (UV) radiation or visible light.

The solar spectrum is composed of various wavelengths of electromagnetic radiation that can penetrate the skin to different levels: the longer…

Currently, the exact mechanism underlying EMPD is unknown, but two widely known theories exist, namely the epidermotropic and transformation theories.

A case of a 25-year-old White female left with residual bone deformity after surgical correction of craniosynostosis during childhood…

The latest research on autoimmune skin disease has studied the efficacy and safety characterisation of guselkumab (GUS), a human monoclonal…

Strober began by summarising his opinion on the key characteristics of anti-IL-23 therapies that support their efficacy for inducing…

Dermatophytes are the keratinophilic moulds living on the superficial layer of human and animal skin and are transmitted by direct and…

A number of misconceptions prevail in nail melanoma. This short essay tries to clarify some of these issues.

Interviewing Peter Lio, Clinical Assistant Professor of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine

The latest international guidelines on urticaria were published in September as a joint initiative from the European Academy of…

Recent years have witnessed significant advances in the understanding of facial anatomy. Extensive studies have uncovered the arrangement of soft-tissue layers underlying the skin and their mobility during expression. Meanwhile, increasing awareness of the facial vascular network has laid the foundation for lower risk cosmetic procedures.

An interview with Roxana Daneshjou, Clinical Scholar of Dermatology, Stanford University, California, USA.

Tuberous sclerosis complex (TSC) is an autosomal dominant hereditary disease with hamartomatous growths in multiple organs due to…

Psoriasis is a chronic inflammatory skin condition that impacts patients’ quality of life and has large economic consequences…

Richard B. Warren highlighted Psoriasis Symptoms and Impacts Measure (P-SIM) responses from the Phase III BE VIVID trial in patients…

In the late-breaking research sessions, Reich presented BE RADIANT, the first Phase III trial to compare inhibition of IL-17A and IL-17F…

This Janssen-sponsored live satellite symposium, entitled ‘Where do we begin? The key role of the IL-23 pathway in psoriasis and psoriatic…

Pioneering global best practices in atopic dermatitis (AD) and implementing them in the clinic are important steps towards optimising patient care…

Botulinum neurotoxins (BoNTs) are derived from Clostridium botulinum, a gram-positive anaerobe. While there are seven subtypes of BoNT (A to G), only A…

The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen and the subsequent coronavirus disease (COVID-19) mainly affect the lung…

Eczematous dermatitis (or eczema) includes AD, CD, and DD. This inflammatory skin reaction presents as erythema, vesicles, desquamation…

Atopic dermatitis (AD), sometimes referred to as ‘atopic eczema’, is a common, chronic, pruritic, Type II inflammatory skin disease which is associated…

At birth, the skin of the newborn suddenly comes into contact with the extrauterine world: a dry and aerobic environment.1 Newborn skin is 40–60%…

Syphilis is a chronic bacterial infection caused by Treponema pallidum subspecies pallidum, known by clinicians for hundreds of years and with more than 5 million new cases diagnosed every year worldwide…

The indicative scaly, erythematous plaques of plaque psoriasis arise because of abnormal interactions between immune system cells and epidermal…

Terrestrial solar UVR consists of UVA (320–400 nm) and UVB (280–320 nm; typically around 295–320nm because of attenuation by the ozone…

Psoriasis, a chronic systemic inflammatory disease with skin manifestations, can be an impediment to daily life. Accordingly…

Prof Reich began by highlighting how insights into the pathophysiology of psoriasis have led to the development and expansion of cytokine-targeted…

The VOYAGE 1 trial1 was a placebo- and active-controlled Phase III study to evaluate long-term efficacy and safety of the IL-23p19 inhibitor guselkumab…

Psoriasis is a Th17-driven disease, with both IL-17A and IL-17F playing a pivotal role in its pathogenesis.2,3 BKZ is a monoclonal IgG1 antibody…

Chronic urticaria (CU) is one of the most commonly diagnosed skin conditions. CU is characterised by the presence of recurrent wheals and/or angioedema…

Recessive dystrophic epidermolysis bullosa (RDEB) and junctional EB (JEB) are inherited disorders characterised by fragility and blistering of epithelial…

With the recent advancements of biologic therapies that block IL-23, there is increasing need for analysis of which biologics are most efficacious…

Stevens–Johnson syndrome and toxic epidermal necrolysis are well-known severe cutaneous adverse reactions, with >100 medications previously implicated…

Ungual psoriasis and onychomycosis are common nail diseases. Despite their different aetiology and course, surprisingly they have much in common.

This clinical dermatology report examines six short case studies of patients diagnosed with acne vulgaris, actinic keratosis (AK), and atopic dermatitis (AD)…

An enhanced understanding of real-world CL Gel usage could help improve the management of patients with MF-CTCL…

Pemphigoid gestationis (PG) is a rare pruritic autoimmune blistering skin disease associated with pregnancy and is classified as a pregnancy-specific…

“Psoriasis isn’t just a skin disease”: depression, anxiety, and alexithymia are common in people living with the condition, as are low self-esteem…

MF-CTCL is a rare type of cutaneous non-Hodgkin’s lymphoma where uncontrolled growth of the pathological skin-homing T-lymphocytes results first in skin…

Cumulative or excessive solar exposure is detrimental to skin health.1 Furthermore, certain population groups require extra care…

Sebaceous carcinoma is a rare and very aggressive malignant skin cancer of the sebaceous gland. While sebaceous glands are present all over the body…

Urticaria is a common mast cell-driven disease characterised by wheals and/or angioedema (), defined as chronic…

Skin diseases such as psoriasis can profoundly influence a patient’s self-image, self-esteem, and sense of wellbeing. The chronic nature of the disease…

Advances in the treatment of moderate-to-severe psoriasis have accelerated considerably in the last 30 years. Prof Piaserico provided an overview of the…

Psoriasis is a chronic, relapsing inflammatory skin disease, characterised in most cases by sharply demarcated, erythematous, pruritic plaques covered…

IL-23 plays a key regulatory role in the pathogenesis of plaque psoriasis and medications targeting IL-23 have been shown to be effective for people with…

Development of psoriasis occurs due to interactions with epidermal keratinocytes and immune-system cells including T-lymphocytes, antigen-presenting…

Psoriasis is associated with high morbidity, causing problems in daily life such as itching and scaling, even for patients with less-severe disease…

Allergies represent a significant, rising health concern. Recent figures indicate that 150 million Europeans experience chronic allergic disease…

The symposium “IL-23 Inhibition: From Pathophysiological Jungle to Clinical Clearance” took place during the 2019 annual European Academy of Dermatology…

Guselkumab was the first monoclonal antibody targeting the p19 subunit of IL-23 (IL-23p19) to be approved for the treatment of psoriasis.

Prof Augustin opened the symposium by underlining how the management of patients with moderate-to-severe atopic dermatitis (AD) has become more dynamic…

Psoriasis and AD are chronic, systemic inflammatory diseases of the skin characterised by upregulation of proinflammatory cytokines…

Acne is the most common skin condition in the USA, affecting over half of its population.1 It is an inflammatory skin disease that predominantly…

Atopic dermatitis (AD) is one of the most common and debilitating chronic inflammatory skin diseases, often greatly affecting physical, economical…

The objectives of this symposium were to understand the importance of planning treatment addressing the specific needs of women living…

Type 2 immunity evolved from a dialogue between the immune system and microbes. This form of immunity confers protection against bacteria, viruses…

Hidradenitis suppurativa, or acne inversa, is a chronic, recurrent inflammatory disease of the skin and subcutaneous tissue characterised by painful…

The main objective of this manuscript is to offer an organised and updated review of the clinical features and current treatment options for paediatric serum sickness-like reaction.

Prof Schaller posed the question “what makes rosacea so special?” and explained that the manifestations of rosacea are very varied, including papules…