Onc Now | Episode 3
This week, Jonathan Sackier is joined by Carlos Caldas, a world-leading expert in breast cancer research and clinician scientist at the University of Cambridge. Together, they explore how genomic-based classifications of breast cancer are transforming treatment strategies and improving patient outcomes.
Apple | Amazon Music | Download MP3 (46 mins)
Carlos Caldas is the Chair of Cancer Medicine at the University of Cambridge and a renowned clinician scientist whose pioneering work has reshaped the understanding of breast cancer. His research, particularly through the METABRIC initiative, has led to the classification of breast cancer into 10 distinct genomic subtypes, paving the way for personalised treatment strategies. Prof. Caldas has received numerous accolades, including the ESMO Hamilton Fairley Award and the Susan G. Komen Brinker Award, for his significant contributions to oncology.
- 00:00 Introduction
- 02:00 Carlos’s favourite cuisine
- 03:32 Carlos’s journey into oncology
- 08:30 The redefinition of breast cancer
- 14:30 How this taxonomy influences clinical care
- 20:15 Patient-derived xenografts for breast cancer
- 28:00 Circulating plasma cell-free tumour DNA as a marker of tumour burden
- 33:00 Patient derived tumour cells for drug screening
- 35:00 Vitamin B5 and environmental factors in oncology
- 38:44 Current developments in breast cancer aetiology, diagnosis or treatment
- 44:00 The three wishes for the future of healthcare
- 45:00 Outro
