A recent study has explored the relationship between chronic pain and the risk of death from cerebrovascular disease in cancer patients. Using data from the Surveillance, Epidemiology, and End Results database, covering the years 1975 to 2019, the researchers conducted a case-control investigation involving 16,850 cancer patients and 710,729 controls. The study aimed to identify factors that could predict mortality from cerebrovascular disease in those with cancer.
The findings revealed that 2.3% of cancer patients died from cerebrovascular disease. Surprisingly, cancer pain, specifically a moderate pain rating, was associated with a decreased risk of death from cerebrovascular disease, suggesting that certain levels of pain may have a protective effect. In contrast, older age at cancer diagnosis, male gender, being unmarried, and not receiving systemic therapy were linked to a higher risk of death from cerebrovascular disease.
The researchers applied machine learning techniques to develop a predictive model for the 5-year and 10-year risk of cerebrovascular disease death in cancer patients. Key factors, including survival time, age, and pain rating, emerged as the most significant variables in predicting outcomes.
This study offers new insights into how chronic pain could serve as a potential protective factor against cerebrovascular disease in cancer patients. By incorporating pain ratings into risk models, the researchers aim to identify those at higher risk of cerebrovascular disease and develop strategies to reduce these risks in cancer patients.
Reference
Wei Y et al. Population data study reveals pain as a possible protective factor against cerebrovascular disease in cancer patients. Scientific Reports. 2024;14:29471.
