RESEARCHERS at the University of Waterloo have developed a revolutionary hydrogel for 3D-printed contact lenses capable of delivering medication directly to the eye.
The groundbreaking hydrogel, created through collaboration between Waterloo’s Department of Chemistry and the School of Optometry and Vision Science, addresses challenges in drug delivery for eye-related conditions. Using a silicone-based material, the hydrogel allows for controlled release of medications, offering an efficient alternative to traditional eye drops.
The research utilised a novel hydrophilic silicone hydrogel that is UV-curable and retains flexibility and durability. Testing involved the incorporation of amoxicillin, a common antibiotic, to evaluate the hydrogel’s drug-release capabilities. Results showed that the macro-porous structure of the hydrogel regulated the release of the medication over time. This controlled delivery reduces the frequency of application, improving patient compliance. The material also demonstrated stability, with encapsulated drugs maintaining their properties after a month of storage. Mechanical tests indicated high elasticity and resilience, essential for sustained wear. Additionally, the hydrogel’s unique characteristics enabled it to be both injectable and printable, ensuring precision in manufacturing.
The findings suggest significant clinical implications. By embedding drugs into contact lenses, patients could experience more consistent medication delivery and reduced application challenges compared to traditional eye drops. The technology could be particularly beneficial for those with chronic conditions requiring frequent treatment. The team’s recent patent filing paves the way for further advancements, including broader applications in ocular therapy and potential use in other biomedical fields. Future research will likely focus on refining drug-release profiles and exploring compatibility with other medications.
Reference
Ganguly S et al. Injectable and 3D extrusion printable hydrophilic silicone-based hydrogels for controlled ocular delivery of ophthalmic drugs. ACS Applied Bio Materials. 2024;DOI:10.1021/acsabm.4c0090.
