Articles

TNF-α is produced in high concentrations in chronic inflammatory disease, resulting in excessive inflammation which eventually leads to organ damage. The advent of anti-TNF therapy in clinical practice 20 years ago represented a significant change in the management of immune-mediated inflammatory diseases (IMIDs), including rheumatoid arthritis (RA), axial spondylarthritis (SpA), psoriasis, and inflammatory bowel disease (IBD).

EMJ team had the pleasure of interviewing two specialists: Mausumi Das, Consultant Gynaecologist and a Subspecialist in Reproductive Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, and Chelsea and Westminster Hospital NHS Foundation Trust, London, UK

EMJ team had the pleasure of interviewing two specialists: Signe Altmäe Department of Biochemistry and Molecular Biology, University of Granada, Spain, and Division of Obstetrics and Gynaecology, Karolina Institutet, Stockholm, Sweden.

Male factor aetiologies account for approximately 50% of infertility in couples, with azoospermia diagnosed in up to 15% of infertile males. The World Health Organization (WHO) semen analysis parameters are universally used and define azoospermia as an absence of spermatozoa identified in wet or centrifuged ejaculate samples.

Endometriosis is characterised by the presence of endometrium-like tissue on the pelvis and other organs. Progesterone resistance due to suppressed progesterone receptor (PGR) expression and action is a general feature of endometriosis and is a cause of endometriosis-associated chronic pelvic pain, infertility, inflammatory disorders, and cancer.

Improving maternal health has been a major concern worldwide. This is evident by maternal health being included in the Millennium Development Goals, with the goal of reducing maternal mortality by three-quarters by 2015, and now the Sustainable Development Goals, with targets set to reduce the global maternal mortality ratio to less than 70 per 100,000 live births.

Diabetic ketoacidosis (DKA), characterised by the triad of acute hyperglycaemia, metabolic acidosis, and ketosis, is an acute life-threatening but preventable complication of diabetes.

Assessment of the ovarian morphology is one of the most commonly performed ultrasound examinations. Polycystic ovarian syndrome (PCOS) is a multifactorial, multifaceted, polygenic disorder with varying phenotypes.