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General Healthcare
30 Dec 2013

Can Periodic Surveillance for Metastases Improve Clinical Outcome in Uveal Melanoma? Moving Towards International Guidelines

Uveal melanoma is a rare disease with a predominant propensity for liver metastasis. Prognosis in the metastatic setting is poor, and no treatments…
EMJ
Hepatology
29 Dec 2013

Towards a Standardised Method to Acquire and Store Liver Samples and Guidelines to Improve Quality Control and Exchange of Relative Expression Data

The current ‘state-of-the-art’ molecular techniques are extremely sensitive and consequently prone to false results. Even more so than in the past…
EMJ
Urology
29 Dec 2013

Viral Proteins Mediate Upregulation of Negative Regulatory Factors Causing Down-Modulated Dendritic Cell Functions In Chronic Hepatitis C Virus Infection

Stunted cellular immune response against a narrow range of epitopes is the hallmark of chronic hepatitis C infection, but the underneath molecular…
EMJ
Hepatology
29 Dec 2013

Management of Hepatitis B Virus Infection in Liver Transplant Recipients

Hepatitis B virus (HBV)-related liver disease is a common indication for liver transplantation (LT) in Asian countries. When left untreated, the overall…
EMJ
Hepatology
29 Dec 2013

IL28B Polymorphisms in Interferon-Treated Patients with Chronic Hepatitis B

Pegylated interferon (Peg-IFN) may achieve a sustained off-treatment response in 20-30% of the patients with chronic hepatitis B (CHB).
EMJ
Hepatology
29 Dec 2013

Cellular Consequences of Z Alpha-1 Antitrypsin Accumulation and Prospects for Therapy

The Z variant (Glu342Lys) of α1-antitrypsin polymerises and accumulates in the hepatocyte endoplasmic reticulum predisposing to neonatal hepatitis…
EMJ
Hepatology
29 Dec 2013

Acute-On-Chronic Liver Failure: Applying the PIRO Concept

Acute-on-chronic liver failure (ACLF), a clinical syndrome associated with a dismal prognosis, occurs acutely in previously stable cirrhotic patients.
EMJ
Hepatology
29 Dec 2013

Adrenal Insufficiency (AI) in Cirrhosis

Adrenal dysfunction or insufficiency (AI) in cirrhosis, also described as hepato-adrenal syndrome, is an only recently recognised entity.