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Hematology
1 Mins
2 Aug 2018

A Targeted Next-Generation Sequencing-Based Diagnosis for Hereditary Anaemias

Anaemia affects 1.6 billion people worldwide, with roughly 10% of these individuals affected by rare anaemias, of which 80% are hereditary. Hereditary…
Hematology
1 Mins
2 Aug 2018

Genes and Pathways Dysregulated by Nilotinib Treatment in Bone Marrow CD34+/Lin- Cells of Patients with Chronic-Phase Chronic Myeloid Leukaemia

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. Specifically, it presents a…
Hematology
2 Mins
2 Aug 2018

A High Pretreatment Bone Marrow CD34+/CD38- Cell Burden in Patients with Myelodysplastic Syndrome is a Prognostic Factor for Disease Progression After Allogeneic Stem Cell Transplantation

Myelodysplastic syndromes (MDS) are highly heterogeneous clonal haematopoietic disorders. Allogeneic haematopoietic stem cell transplantation (HSCT)…
Hematology
2 Mins
2 Aug 2018

Longitudinal Trend Analysis of Serum Transferrin Receptor-1 Level in a Cohort of 104 Patients Affected by Non-Transfusion-Dependent Thalassaemia

The proper management of patients with non-transfusion-dependent thalassaemia (NTDT) has been a challenging mission. In fact, NTDT encompasses a great…
Hematology
1 Mins
2 Aug 2018

Combined Oral Administration of Analgesia and Anxiolysis for Pain Associated with Bone Marrow Aspiration and Biopsy

Bone marrow aspiration and biopsy (BMAB) is a painful procedure. The commonly adopted local infiltration anaesthesia (LIA) with lidocaine is unable to…
Hematology
1 Mins
2 Aug 2018

Novel Agents for the Management of Relapsed Multiple Myeloma

Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. MM accounts…
Rheumatology
1 Mins
31 Jul 2018

Treating Rheumatoid Arthritis to Target: Is Low Disease Activity Good Enough?

Treat-to-target principles in rheumatoid arthritis (RA) are now widely recognised as effective in achieving optimal disease outcomes. This study examined…
Rheumatology
2 Mins
31 Jul 2018

Physician Global Assessments for Disease Activity in Rheumatoid Arthritis Are All Over the Map!

There have been many studies about patient global assessments of disease activity in rheumatoid arthritis (RA) and how these differ from physician global…