Hematology

Mycosis fungoides (MF) and Sézary syndrome (SS), two of the most-studied types of cutaneous T-cell lymphoma (CTCL), account for approximately 60% and 10% of CTCL cases, respectively.

We are talking about 35 years ago, and some of what drew me to the practice is still true today. There were two major aspects of cancer…

von Willebrand factor (VWF) is a large, adhesive, multimeric protein involved in haemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein.

Multiple myeloma is a haematological malignancy predominantly affecting older people and has a median age of onset of 70 years.

β-thalassaemias are a clinically heterogenous group of inherited disorders caused by >200 described mutations in the β-globin gene, leading to a decreased or absent production of the β-globin chain.

Polycythaemia vera (PV) is a condition characterised by an increasing number of the red blood cells in the blood.

Eduard Glanzmann first reported Glanzmann thrombasthenia (GT) in 1918 after he identified a functional abnormality of platelets with defective clot retraction.

Mutations in FLT3 are the most common genetic alteration in AML. Patients with a FLT3 internal tandem duplication (ITD) mutation subtype have poor prognosis, especially when there is a high allelic burden.