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31 Jul 2014

The Role of CD49d in Chronic Lymphocytic Leukaemia: Microenvironmental Interactions and Clinical Relevance

Chronic lymphocytic leukaemia (CLL) is a clinically heterogeneous disease characterised by the accumulation/expansion of a clonal population of…
31 Jul 2014

Current Developments and Perspectives in Multiple Myeloma

In the last decades, advances in the therapeutic management of multiple myeloma (MM) with new drug armamentarium and strategies have significantly…
31 Jul 2014

Autologous Stem Cell Transplantation In Multiple Myeloma: Is It Still The Right Choice?

Autologous stem cell transplantation (ASCT) is considered the standard of care for multiple myeloma patients aged <65 years with no relevant…
31 Jul 2014

The Role of JAK2 Mutation in Thrombotic Complications of Chronic Myeloproliferative Neoplasms

Patients diagnosed with myeloproliferative neoplasms (MPNs) often develop thrombotic events as an onset of symptoms or in evolution. The pathogenesis of…
31 Jul 2014

Calreticulin in Myeloproliferative Neoplasms: The Other Side of the Alice Mirror

Calreticulin (CALR), a Ca2+ binding protein mostly localised in the endoplasmic reticulum, regulates Ca2+ homeostasis, chaperones, and other proteins to…
31 Jul 2014

Iron Supplementation for Perioperative Anaemia in Patient Blood Management

In patients undergoing major surgical procedures, preoperative anaemia and perioperative allogeneic blood transfusion (ABT) have been linked to increased…
31 Jul 2014

Looking Back To Our Roots: 80 Years of Wintrobe’s Indices

This year (2014) we are celebrating the 80th anniversary of Dr Maxwell Myer Wintrobe’s pioneer works, one of the most important contributions in clinical…
1 Aug 2013

Delayed Erythroid and Platelet Response to Eculizumab in Paroxysmal Nocturnal Haemoglobinuria - A Case Report and Literature Review

Paroxysmal nocturnal haemoglobinuria (PNH) is an acquired clonal disorder of haemopoiesis characterised by haemolytic anaemia, thrombophilia and variable…