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9 Mins
2 Aug 2018

Editor's Pick: Allogeneic Haematopoietic Stem Cell Transplantation for Chronic Myeloid Leukaemia in the Era of Tyrosine Kinase Inhibitors

The introduction of tyrosine kinase inhibitors (TKI) has dramatically improved the prognosis of chronic myeloid leukaemia (CML) patients and, therefore…
10 Mins
2 Aug 2018

Therapeutic Options in Myelodysplastic Syndromes: Established and Emerging Therapies

Although hypomethylating agents (HMA) have revolutionised the treatment of myelodysplastic syndromes (MDS), a significant proportion of patients either…
11 Mins
2 Aug 2018

Making Rituximab Directly Cytotoxic for Substantial Improvement in Therapeutic Efficacy

The humanised anti-CD20 antibody (Ab) rituximab (RTX) has significantly improved the prognosis of B cell non-Hodgkin’s lymphomas (BNHL). However, major…
12 Mins
2 Aug 2018

Staging of Mycosis Fungoides and Sézary Syndrome: Time for an Update?

Mycosis fungoides is the most common variant of cutaneous T cell lymphoma and frequently presents as early-stage disease with skin patches and plaques with an indolent course, but patients experience significant morbidity from itch and disfigurement.
12 Mins
2 Aug 2018

Iron Deficiency Anaemia in Pregnancy: Developed Versus Developing Countries

Anaemia is the most widespread of the haematological disorders, affecting about one-third of the global population. Despite decades of public health…
12 Mins
7 Jun 2018

Multiple Myeloma: Personalised Medicine Based on Pathogenesis

Multiple myeloma is increasingly being recognised as more than one disease, characterised by marked cytogenetic, molecular, and proliferative heterogeneity.
10 Mins
22 Sep 2017

β-Thalassaemias: Highlights from the European Hematology Association Scientific Working Group (EHA-SWG) Scientific Meeting on Anaemias: Diagnosis and Treatment in the Omics Era

β-thalassaemias are inherited blood disorders caused by a defect in the production of β-globin, giving rise to variable phenotypes.
4 Mins
31 Aug 2017

How I Manage Myelofibrosis

Myelofibrosis (MF), either primary or secondary to polycythaemia vera or essential thrombocythaemia, is the most symptomatic and has the worst prognosis…