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28 Jul 2016

GBT440, a Novel Sickle Haemoglobin Polymerisation Inhibitor, Increases Haemoglobin Oxygen Affinity and Results in a Rapid Improvement in Haemolysis and Anaemia

GBT440 is a novel, small molecule haemoglobin oxygen affinity modifier. In vitro data has shown that by increasing sickle haemoglobin (HbS) oxygen…
2 Mins
28 Jul 2016

Role of the Calreticulin Gene and Its Deregulation in Myeloproliferative Neoplasms

Polycythaemia vera (PV), essential thrombocythaemia (ET), and primary myelofibrosis (PMF) are the three classical Philadelphia chromosome-negative…
2 Mins
28 Jul 2016

Family-Directed Cord Blood Banking for Sickle Cell Disease: A 20-Year Experience on Behalf of Eurocord-Monacord and the International Sickle Cell Disease Observatory

Cord blood transplantation (CBT) from a related family member is an effective therapy for patients with sickle cell disease (SCD) resulting in…
1 Mins
28 Jul 2016

Real-World Experience of Ibrutinib in More Than 700 Patients with Mantle Cell Lymphoma: Data from a Global Named Patient Programme

Mantle cell lymphoma (MCL) is an uncommon but aggressive form of B cell non-Hodgkin lymphoma. It often presents at an advanced stage and with a median…
2 Mins
28 Jul 2016

The Spectrum of Late Effects After Cancer: Lessons from Paediatric Oncology and the Value of International Collaboration

This presentation described the occurrence of late side effects (commonly described as ‘late effects’) in childhood cancer survivors (CCS), and how…
1 Mins
28 Jul 2016

Chronic Lymhocytic Leukaemia: Treatment of the Elderly

Chronic lymphocytic leukaemia (CLL) mainly affects elderly patients.1 With the increasing comorbidity burden and frailty in elderly patients, evaluation…