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1 Mins
2 Aug 2018

Bacterial Contamination of Platelet Transfusion Units Affects Platelet Haemostatic Function and Immunological Activity

Transfusion-associated bacterial infection is a major risk of platelet transfusion and can be fatal. The storage requirements of platelet concentrates…
2 Mins
2 Aug 2018

Lenalidomide: The Gift That Keeps on Giving

First-line therapy for indolent non-Hodgkin’s lymphoma usually consists of a combination of rituximab-based chemoimmunotherapy. Historically, first-line…
1 Mins
2 Aug 2018

A Targeted Next-Generation Sequencing-Based Diagnosis for Hereditary Anaemias

Anaemia affects 1.6 billion people worldwide, with roughly 10% of these individuals affected by rare anaemias, of which 80% are hereditary. Hereditary…
1 Mins
2 Aug 2018

Genes and Pathways Dysregulated by Nilotinib Treatment in Bone Marrow CD34+/Lin- Cells of Patients with Chronic-Phase Chronic Myeloid Leukaemia

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. Specifically, it presents a…
2 Mins
2 Aug 2018

A High Pretreatment Bone Marrow CD34+/CD38- Cell Burden in Patients with Myelodysplastic Syndrome is a Prognostic Factor for Disease Progression After Allogeneic Stem Cell Transplantation

Myelodysplastic syndromes (MDS) are highly heterogeneous clonal haematopoietic disorders. Allogeneic haematopoietic stem cell transplantation (HSCT)…
2 Mins
2 Aug 2018

Longitudinal Trend Analysis of Serum Transferrin Receptor-1 Level in a Cohort of 104 Patients Affected by Non-Transfusion-Dependent Thalassaemia

The proper management of patients with non-transfusion-dependent thalassaemia (NTDT) has been a challenging mission. In fact, NTDT encompasses a great…
1 Mins
2 Aug 2018

Combined Oral Administration of Analgesia and Anxiolysis for Pain Associated with Bone Marrow Aspiration and Biopsy

Bone marrow aspiration and biopsy (BMAB) is a painful procedure. The commonly adopted local infiltration anaesthesia (LIA) with lidocaine is unable to…
1 Mins
2 Aug 2018

Novel Agents for the Management of Relapsed Multiple Myeloma

Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. MM accounts…