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EMJ Hematology US 1.1 2020
1 Mins
24 Jan 2020

Assessment of Mortality and its Associated Risk Factors in Patients with Transfusion-Dependent Thalassaemia in India

India is home to approximately 100,000 people living with transfusion-dependent severe thalassaemia,1 and yet very little data on survival are available…
EMJ Hematology US 1.1 2020
2 Mins
24 Jan 2020

Lactate Release by Inflammatory Bone Marrow Neutrophils Induces their Mobilisation via Endothelial GPR81 Signalling

Innate immune neutrophils provide the first line of host defence against bacterial infections.
1 Mins
1 Aug 2019

Tagraxofusp is a Novel Targeted Therapy Directed to CD123

Blastic plasmocytoid dendritic cell neoplasm (BPDCN), a rare, highly aggressive haematologic malignancy, often with cutaneous and other extramedullary…
1 Mins
1 Aug 2019

Post-Transplant Cyclophosphamide in HLA Matched and Haploidentical Transplant Recipients Receiving Myeloablative Timed Sequential Busulfan Conditioning Regimen: Results of a Phase II Study

The authors report a prospective Phase II trial to assess (a) if post-transplant cyclophosphamide (PTCy) could be safely incorporated in a timed…
1 Mins
1 Aug 2019

Autologous Dendritic Cell Vaccination to Prevent Progression and Relapse in Multiple Myeloma

Data from the National Cancer Institute showed that 50% of myeloma patients survive past 5 years post-diagnosis. This is encouraging but also warns…
2 Mins
1 Aug 2019

Gilteritinib Plus Azacitidine in Newly Diagnosed FLT3 Mutated (FLT3mut+) Acute Myeloid Leukaemia Patients Ineligible for Intensive Induction Chemotherapy: Preliminary Findings from the Safety Cohort

Search of more effective treatment for patients with acute myeloid leukaemia (AML) who are ineligible for intensive chemotherapy remains challenging…
2 Mins
2 Aug 2018

Polymorphisms in Multidrug Resistance Transporter Genes Affect the Duration of Molecular Response to Nilotinib in Chronic Myeloid Leukaemia Patients

Despite the high efficacy and improved clinical response of nilotinib in chronic myeloid leukaemia (CML), there is still a significant proportion of…
2 Mins
2 Aug 2018

Inherited Platelet Disorders Caused by Thrombopoietin Mutation

Thrombopoietin (THPO) and the interaction with its receptor c-Mpl have a nonredundant role in platelet biogenesis and maintenance of the haematopoietic…