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hematology 8.1 featured image
2 Mins
30 Jul 2020

Implementation of Haematological Malignancies Patient-Reported Outcome Measure in Clinical Practice: Haematologists’ Experience

Patients with haematological malignancies (HM) may experience significantly compromised quality of life (QoL) as a result of the disease and its…
hematology 8.1 featured image
2 Mins
30 Jul 2020

Integrative Analysis of the Genomic Landscape of Hodgkin Lymphoma Using Liquid Biopsies

The genomic landscape of Hodgkin lymphoma (HL) is not well understood because of the scarcity of Hodgkin-Reed–Sternberg cells, which makes conventional…
hematology 8.1 featured image
2 Mins
30 Jul 2020

Mechanistic Insights into the Inhibition of Regulatory T Cells by Dasatinib in Chronic Myeloid Leukaemia Patients with Clonal Lymphocytosis

Dasatinib is a potent inhibitor of lymphocyte-specific protein tyrosine kinase (Lck), which plays a pivotal role in T-cell receptor (TCR) signalling…
hematology 8.1 featured image
2 Mins
30 Jul 2020

Identification of HIF2α as a Novel Determinant of Acute Myeloid Leukaemia Block of Differentiation Poses its Inhibition as a Potential Therapeutic Opportunity for Acute Myeloid Leukaemia Patients

Signalling via hypoxia inducible factors (HIF)1α and HIF2α is importantly implicated in cancer,1 although it has been predominantly studied in solid…
hematology 8.1 featured image
1 Mins
30 Jul 2020

Comparison of Decitabine with Venetoclax versus Intensive Chemotherapy Using Propensity Score Matching and Treatment-related Mortality Risk Scoring

Acute myeloid leukaemia (AML) usually presents in older patients over the age of 65 years.1 A large proportion of such patients are frail or have…
EMJ Hematology US 1.1 2020
2 Mins
24 Jan 2020

Fli-1 Transcriptionally Integrates Microenvironmental Cues Sensing by Self-Renewing Haematopoietic Stem and Progenitor Cells

During adulthood and embryogenesis, fate decisions of haematopoietic stem and progenitor cells (HSPC), such as specification, self-renewal, and…
EMJ Hematology US 1.1 2020
2 Mins
24 Jan 2020

Novel CD33 Antibodies Reveal CD33 Splicing Polymorphism Variant Localisation and Therapeutic Implications

Acute myeloid leukaemia (AML) is a heterogeneous haematologic malignancy characterised by dysfunctional proliferation and differentiation of myeloid progenitor cells.
EMJ Hematology US 1.1 2020
2 Mins
24 Jan 2020

Safety and Efficacy of 1,020 mg Total Dose Infusion of Ferumoxytol in a Veterans Health System

Ferumoxytol is an intravenous (IV) formulation of iron that can be infused quickly, making it a convenient choice.