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20 Nov 2018

High Low-Density Lipoprotein Cholesterol Levels and Risk of Peripheral Vascular Diseases: A Mendelian Randomisation Study Including 116,419 Individuals From The General Population

High low-density lipoprotein (LDL) cholesterol levels are causally involved in the pathogenesis of atherosclerosis and are related to an increased risk…
2 Mins
20 Nov 2018

Inhibition of Insulin Secretion by Cxcl14

G protein-coupled receptors are tractable targets for pharmacotherapies;1 however, challenges arise when it is necessary to either deorphanise a known…
2 Mins
20 Nov 2018

IRS1 Genetic Variants Associated with Glucose Control and Insulin Resistance in Type 2 Diabetes Mellitus Patients from Bosnia And Herzegovina

Previous studies have reported conflicting results regarding the association of IRS1 gene variation with Type 2 diabetes mellitus (T2DM) and insulin…
1 Mins
31 Oct 2017

A Role for Connexin Mediated Cell Communication in Fibrosis of Tubular Epithelial Cells in the Diabetic Kidney

Diabetic nephropathy represents the leading cause of end-stage renal disease and is the greatest cause of patient entry into the renal replacement…
2 Mins
31 Oct 2017

Sex Differences in the Diabetes-Associated Risk of Cardiovascular Events in a Young Population

The diabetes-associated excess risk of cardiovascular diseases is known to be higher in women than in men. Find out more in the article
2 Mins
31 Oct 2017

Short-Term Renal Effects of Vildagliptin Addition and Their Clinical and Laboratory Predictors in Insulin-Treated Type 2 Diabetes Mellitus Patients: A Randomised, Comparative, Prospective Clinical Study

Positive renal effects of vildagliptin have been shown by several experimental studies.1,2 Nonetheless, clinical evidence for its renoprotective…
2 Mins
31 Oct 2017

Acute Endothelial Benefits of Fat Restriction Over Carbohydrate Restriction in Type 2 Diabetes Mellitus

The current ‘Western cluster’ of non-communicable disorders could be redefined as a dysfunction of the heterogenic, complex, and bidirectional metabolic…
2 Mins
31 Oct 2017

Duration-8 Randomised Controlled Trial 1-Year Results: Efficacy and Safety of Once-Weekly Exenatide Plus Once-Daily Dapagliflozin Versus Exenatide or Dapagliflozin Alone

Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors have complementary mechanisms of action.