A RECENT analysis of National Health and Nutrition Examination Survey (NHANES) data from 1999–2018 has revealed a strong association between novel inflammatory markers and osteoporosis risk in elderly patients. The study underscores the potential role of inflammation in bone health, highlighting key biomarkers that could aid in early detection and risk assessment of osteoporosis.
Researchers analysed bone mineral density (BMD) data from 837 elderly individuals (mean age: 68.3 years), using dual-energy X-ray absorptiometry. Osteoporosis indices were calculated and assessed in relation to three inflammatory markers, AISI (Aggregated Inflammatory Risk Index), SIRI (Systemic Inflammation Response Index), and SII (Systemic Immune-Inflammation Index)—which were derived from blood counts of lymphocytes, neutrophils, monocytes, platelets, and albumin.
Findings showed that higher levels of AISI, SIRI, and SII were significantly correlated with lower BMD and an increased risk of osteoporosis. These markers may provide a convenient, objective way to predict osteoporosis risk, particularly in older adults where chronic inflammation plays a role in bone degradation.
Although the study supports a strong link between systemic inflammation and osteoporosis, researchers emphasised the need for larger, more diverse population studies to confirm these findings and explore potential therapeutic implications.
Aleksandra Zurowska, EMJ
Reference
Yin W et al. Association of novel inflammatory markers with osteoporosis index in older spine osteoporosis patients: NHANES 1999–2018 cross-sectional study. Sci Rep. 2025; DOI: 10.1038/s41598-025-93378-7.
