Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis - European Medical Journal

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Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis

Rheumatology
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Authors:
Morten Herlin,1,2 Michael B. Petersen,,1,2 *Troels Herlin3

1. Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark
2. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
3. Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
*Correspondence to [email protected]

Disclosure:

No potential conflict of interest.

Received:
04.04.14
Accepted:
26.05.14
Citation:
EMJ Rheumatol. ;1[1]:73-83. DOI/10.33590/emjrheumatol/10313716. https://doi.org/10.33590/emjrheumatol/10313716.
Keywords:
Juvenile idiopathic arthritis, arthritis, juvenile, genetics, genetic predisposition to disease, individualised medicine.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

Abstract

Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as playing a key role in JIA development. This review summarises the present knowledge of human leukocyte antigen (HLA) and non-HLA polymorphisms conferring disease susceptibility, and discusses the areas in JIA genetics, which are still to be investigated in order to apply JIA genetics in a clinical setting.

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