Role of Nuclear Receptors in Spontaneous and Recurrent Miscarriage - European Medical Journal

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Role of Nuclear Receptors in Spontaneous and Recurrent Miscarriage

Reproductive Health
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Authors:
*Julia Knabl,1 Aurelia Vattai,1 Brigitte Ziegelmüller,2 Nina Ditsch,1 Udo Jeschke1

1. Department of Obstetrics and Gynecology, Ludwig Maximilian University of Munich, Munich, Germany
2. Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany
*Correspondence to [email protected]

Disclosure:

The authors have declared no conflicts of interest.

Received:
26.01.15
Accepted:
21.04.15
Citation:
EMJ Repro Health. ;1[1]:95-100. DOI/10.33590/emjreprohealth/10311279. https://doi.org/10.33590/emjreprohealth/10311279.
Keywords:
liver X receptor (LXR), Miscarriage, nuclear receptor, peroxisome proliferator-activated receptor (PPAR), recurrent miscarriage, retinoid X receptor (RXR), thyroid hormone receptor (THR)

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

Abstract

Although early pregnancy loss is a common complication of human reproduction, a significant proportion of miscarriages still happen for unknown reasons. Nuclear receptors are key players in trophoblast invasion and metabolism; therefore, their agonists and ligands are a promising target for the prevention of miscarriage. This review gives an overview of the existing data and literature concerning the involvement of nuclear receptors in maintaining a viable pregnancy.

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