Diagnostic Performance of Neural Network Algorithms in Skull Fracture Detection on CT Scans: A Systematic Review and Meta-Analysis - European Medical Journal

Diagnostic Performance of Neural Network Algorithms in Skull Fracture Detection on CT Scans: A Systematic Review and Meta-Analysis

1 Mins
Radiology
Authors:
Ramtin Hajibeygi , 1 Guive Sharifi , 2 Mobina Fathi , 3 Ashkan Bahrami , 4 Reza Eshraghi , 4 Irene Dixe de Oliveira Santon , 5 Arshia Mirjafari , 6 Janine S. Chan , 7 * Long H. Tu 5
  • 1. Tehran University of Medical Sciences, School of Medicine, Iran
  • 2. Skull base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 3. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 4. Student Research Committee, Faculty of Medicine, Kashan University of Medical Science, Iran
  • 5. Department of Radiology and Biomedical Imaging, Yale School of Medicine, Connecticut, USA
  • 6. Department of Radiological Sciences, University of California, Los Angeles, USA
  • 7. Keck School of Medicine of USC, Los Angeles, California, USA
*Correspondence to [email protected]
Disclosure:

The authors declare they have no conflict of interest.

Citation:
EMJ Radiol. ;6[1]:36-37. https://doi.org/10.33590/emjradiol/UVCK5966.
Keywords:
Convolutional neural networks, deep learning, fracture, skull.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

BACKGROUND AND AIM

Radiologists who evaluate CT scans have diagnostic challenges due to the complexity of underlying anatomy and the potential intricacy of skull fractures. The lack of radiologists and the increasing need for quick and precise fracture diagnosis have highlighted the need for automated diagnostic technologies.1,2 Deep learning (DL) is used by convolutional neural networks (CNN), a promising new class of medical imaging technology, to increase the accuracy of diagnoses. This systematic review and meta-analysis study aims to evaluate CNN’s ability to identify skull fractures on CT scans.3

METHODS

Studies published before 2024 that employed CNN models to identify skull fractures on CT scans were found using PubMed, Scopus, and Web of Science. Sensitivity, specificity, accuracy, and the area under the curve (AUC) were all analysed. To evaluate publication bias, Egger’s and Begg’s tests were employed with STATA version 15.

RESULTS

A meta-analysis of 11 trials including 20,798 patients was conducted. When pre-training for transfer learning was incorporated into CNN training model, the pooled average AUC was 0.96±0.02. The combined averages for specificity and sensitivity were 0.93 and 1.0, respectively. An accuracy of 0.92±0.04 was achieved. Research revealed heterogeneity, which was accounted for by variations in training models, validation methods, and model topologies. No significant publication bias was seen.

CONCLUSION

CNN models are effective in detecting skull fractures on CT scans. The results indicate that CNN models have the potential to increase diagnostic accuracy in the imaging of acute skull trauma, despite significant variability and potential publication bias. Future research could focus on the usefulness of DL models in prospective clinical trials to further improve these models’ practical application.4,5

References
Gakuu LN. The challenge of fracture management in osteoporotic bones. East African Orthopaedic Journal. 2011;DOI:10.4314/eaoj.v4i1.63606. Scheyerer MJ et al. Osteoporotic fractures of axial skeleton. Praxis. 2012;101(16):1021-30. Chung SW et al. Automated detection and classification of the proximal humerus fracture by using deep learning algorithm. Acta Orthop. 2018;89(4):468-73. Lindsey R et al. Deep neural network improves fracture detection by clinicians. Proc Natl Acad Sci U S A.2018;115(45):11591-6. Blüthgen C et al. Detection and localization of distal radius fractures: deep learning system versus radiologists. Eur J Radiol. 2020;126:108925.

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