This video presents an integrated symposium hosted by Ipsen at the Annual Meeting of the European Association for the Study of Liver (EASL) 2024, which took place in Milan, Italy.
As a rare disease, progressive familial intrahepatic cholestasis (PFIC) may not immediately be suspected in adults presenting with pruritus and cholestasis.1,2 Early diagnosis offers the potential to halt progressive disease and limit liver damage.3,4,5
At EASL 2024, Thomas Berg (Germany), Palak Trivedi (UK), and Filomena Morisco (Italy) reviewed PFIC as a potential cause of unexplained cholestasis and pruritus in adults and described best practice in diagnosing and managing this disease.
Symposium agenda
- Current understanding of adult-onset PFIC;
- Genetic variants associated with cholestasis in adult clinical practice;
- The challenge of clinically diagnosing adult-onset PFIC: a patient case; and
- Building management strategies for adult-onset PFIC.
This promotional symposium was funded and organised by Ipsen, for healthcare professionals only. Prescribing information and adverse event reporting details will be available at the end of the on-demand recording.
Prescribing Information: Click here for prescribing information.
Adverse event reporting:
| ▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions to [email protected] and via the national reporting system as described in section 4.8 of the product prescribing information. |
References
1. McKiernan P et al. Opinion paper on the diagnosis and treatment of progressive familial intrahepatic cholestasis. JHEP Rep. 2023;6(1):100949.
2. Srivastava A. Progressive familial intrahepatic cholestasis. J Clin Exp Hepatol. 2014;4(1):25-36.
3. Thompson RJ et al. Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial. Lancet Gastroenterol Hepatol. 2022;7(9):830-42.
4. Gunaydin M, Bozkurter Cil AT. Progressive familial intrahepatic cholestasis: diagnosis, management, and treatment. Hepat Med. 2018;10:95-104.
5. Clemson AASLD 2022 presentation.
Job code: BYL-ALL-000772
Date of Prep: June 2024
