Uncategorised - European Medical Journal

EMJ

Cellular Consequences of Z Alpha-1 Antitrypsin Accumulation and Prospects for Therapy

The Z variant (Glu342Lys) of α1-antitrypsin polymerises and accumulates in the hepatocyte endoplasmic reticulum predisposing to neonatal hepatitis…

EMJ

Acute-On-Chronic Liver Failure: Applying the PIRO Concept

Acute-on-chronic liver failure (ACLF), a clinical syndrome associated with a dismal prognosis, occurs acutely in previously stable cirrhotic patients.

EMJ

Adrenal Insufficiency (AI) in Cirrhosis

Adrenal dysfunction or insufficiency (AI) in cirrhosis, also described as hepato-adrenal syndrome, is an only recently recognised entity.

EMJ

Hepatic Encephalopathy: A Paradigm Shift

The most recent understanding of the pathogenesis of hepatic encephalopathy (HE) is that heterogeneous precipitating factors cause a low-grade cerebral…

Treatment of Hepatic Encephalopathy – Targeting the Gut-Liver-Brain Axis

Summary of Presentations from the Norgine Sponsored Satellite Symposium, UEG Week, Berlin, Germany, 12th–16th October 2013

State-of-the-Art Treatment of Irritable Bowel Syndrome – Recent Advances and Emerging Therapeutic Alternatives

Irritable bowel syndrome (IBS) is a highly prevalent functional disorder characterised by chronic and recurrent abdominal pain and altered bowel habit.

Understanding the Pathophysiology of IBS

While irritable bowel syndrome (IBS) is still considered a ‘disorder of gut function’ and is diagnosed on the basis of symptoms, evidence is growing to…

Practical Evaluation and Handling of Patients with Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a functional bowel disorder by unknown aetiology. Several reviews are written about pharmacological and psychological…

Endoscopic Optical Enhancement Technologies in IBD

Optical enhancement technologies are emerging as promising tools to improve diagnosis and clinical management of patients with IBD.

Adhesion Molecules as a Therapeutic Target in IBD

Recruitment of circulating leukocytes to areas of inflammation is a key process in the pathophysiology of inflammatory bowel diseases, including…