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8 Mins
1 Dec 2016

Editor’s Pick: “Should I Be Concerned with the Long-Term Use of Proton Pump Inhibitor Therapy?”

Proton pump inhibitors (PPI) are one of the most widely prescribed drugs worldwide. They are the mainstay for treatment of most gastric acid-related…
2 Mins
1 Dec 2016

Feasibility, Safety, and Efficacy of Knife-assisted Resection of Rectal Polyps Extending to the Dentate Line: How Low Can You Go?

Rectal polyps extending to the dentate line (RPDL) pose a technical challenge to endoscopic resection due to the narrow lumen and more.
11 Mins
1 Dec 2016

Assessing Alterations in Food Preference as a Mechanism Contributing to Weight Loss After Gastric Bypass Surgery

Roux-en-Y gastric bypass (RYGB) surgery is a very successful option for the management of obesity, and our understanding of how this intervention…
1 Mins
1 Dec 2016

Enhanced Diagnostic Performance of Symptom-Based Criteria for Irritable Bowel Syndrome by History and Diagnostic Evaluation

As clinicians, we are encouraged to use symptom-based diagnostic criteria to diagnose irritable bowel syndrome (IBS). The Rome III criteria have been…
10 Mins
1 Dec 2016

Eosinophilic Oesophagitis: From Rare to Commonplace, What Are the Potential Explanations?

In this century, eosinophilic oesophagitis (EoE) has become a more recognised allergic disease, resulting in the publication of two consensus reports…
2 Mins
1 Dec 2016

A Randomised Controlled Trial Comparing Air Insufflation, Water Immersion, and Water Exchange for Adenoma Detection in Screening Colonoscopy Patients

Low adenoma detection rate (ADR, proportion of patients with at least one adenoma found in the colon) is correlated with the risk of post-colonoscopy…
10 Mins
1 Dec 2016

Eosinophilic Oesophagitis: Current Understanding and Future Directions

Eosinophilic oesophagitis (EoE) is an emerging disorder that manifests clinically with characteristic symptoms of oesophageal dysfunction…
1 Mins
1 Dec 2016

Pancreatic Cancer: The Role of Cancer-Associated Fibroblasts in Drug Metabolism

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a 5-year survival rate of only 8%. Within the USA, PDAC is expected to become…
2 Mins
1 Dec 2016

Endoscopic Mucosal Resection for Large Sessile Colonic Polyps (≥2 cm) Over a 9-Year Period: A Single-Centre Experience and Analysis of Changes Over Time in a University Teaching Hospital

Endoscopic mucosal resection (EMR) has become the standard technique for resection of large sessile and flat colonic polyps. We aimed to assess the…
9 Mins
1 Dec 2016

Infliximab and Tumour Necrosis Factor Alpha Measurement on Intestinal Mucosa: A New Tool for the Clinic?

Background: Infliximab (IFX) trough levels measurement could partially explain mechanisms of loss in response to this drug.