louisakewell, Author at European Medical Journal - Page 50 of 153

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10 Mins
1 Dec 2016

Eosinophilic Oesophagitis: From Rare to Commonplace, What Are the Potential Explanations?

In this century, eosinophilic oesophagitis (EoE) has become a more recognised allergic disease, resulting in the publication of two consensus reports…
2 Mins
1 Dec 2016

A Randomised Controlled Trial Comparing Air Insufflation, Water Immersion, and Water Exchange for Adenoma Detection in Screening Colonoscopy Patients

Low adenoma detection rate (ADR, proportion of patients with at least one adenoma found in the colon) is correlated with the risk of post-colonoscopy…
10 Mins
1 Dec 2016

Eosinophilic Oesophagitis: Current Understanding and Future Directions

Eosinophilic oesophagitis (EoE) is an emerging disorder that manifests clinically with characteristic symptoms of oesophageal dysfunction…
1 Mins
1 Dec 2016

Pancreatic Cancer: The Role of Cancer-Associated Fibroblasts in Drug Metabolism

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a 5-year survival rate of only 8%. Within the USA, PDAC is expected to become…
2 Mins
1 Dec 2016

Endoscopic Mucosal Resection for Large Sessile Colonic Polyps (≥2 cm) Over a 9-Year Period: A Single-Centre Experience and Analysis of Changes Over Time in a University Teaching Hospital

Endoscopic mucosal resection (EMR) has become the standard technique for resection of large sessile and flat colonic polyps. We aimed to assess the…
9 Mins
1 Dec 2016

Infliximab and Tumour Necrosis Factor Alpha Measurement on Intestinal Mucosa: A New Tool for the Clinic?

Background: Infliximab (IFX) trough levels measurement could partially explain mechanisms of loss in response to this drug.
2 Mins
1 Dec 2016

Unsupervised Transcriptomics-Based Clustering of Ulcerative Colitis Patients Reveals Marked Heterogeneity that Relates to Anti-Tumour Necrosis Factor Treatment Response

Heterogeneity within inflammatory bowel disease cohorts is often cited as the biggest challenge to reliably studying the clinical efficacy of therapeutics.
11 Mins
1 Dec 2016

Barrett’s Oesophagus in 2016

Barrett’s oesophagus (BO) is one of the most important complications of gastro-oesophageal reflux disease as it may progress to oesophageal adenocarcinoma.
6 Mins
1 Dec 2016

Monoclonal Antibody-Based Therapy for Eosinophilic Oesophagitis

Eosinophilic oesophagitis is an inflammatory condition associated with marked eosinophil accumulation in the mucosal tissues of the oesophagus.
2 Mins
1 Dec 2016

Addition of a Solid Test Meal to Oesophageal High Resolution Manometry Improves Diagnostic Yield And Identifies Dysmotility as the Cause of Patient Symptoms

The use of oesophageal high resolution manometry (HRM) to evaluate patients who present with oesophageal symptoms in the absence of a structural lesion…