European Archives - Page 716 of 1370 - European Medical Journal

Central Role of Mast Cells in Associated Disorders

Mast cells are the central cells in the pathogenesis of many conditions that are associated with mediator release. New information is emerging about the role of mast cells in a number of conditions. This review summarises current knowledge on the topic.

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Hereditary Angioedema Management: From Dealing to Leading

A two-part digital symposium series entitled ‘Hereditary Angioedema (HAE) Management: From Dealing to Leading,’ took place during the European Academy of Allergy and Clinical Immunology (EAACI) Hybrid Congress, held in Prague, Czechia, in July 2022.

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Epinephrine Auto-Injector Prescription and Use: A Retrospective Analysis and Clinical Risk Assessment of Adult Patients Sensitised to Lipid Transfer Protein

Lipid transfer proteins (LTPs) are allergens widespread in plant foods. They represent the main cause of food allergy in adults living in the Mediterranean Basin.1,2 The manifestation and severity of LTP hypersensitivity are extremely variable.

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Establishing New Standards in Hereditary Angioedema: Improving Outcomes Through Routine Prophylaxis

Hereditary angioedema (HAE) is a rare but debilitating and potentially fatal disease that presents in various forms, and can be difficult to manage. Its underlying cause is mutations in a gene that, through its protein product, controls production of the tissue enzyme kallikrein and a peptide mediator, bradykinin. The resulting overproduction of bradykinin leads to increased vascular permeability and oedema.

Frequent Use of Moist Wipes During COVID-19: Allergic Sensitisations

During the COVID-19 pandemic, frequent handwashing and disinfection have exacerbated or caused skin diseases. This case report shows the simultaneous development of allergic contact dermatitis to Kathon CG (DuPoint, Wilmington, Delaware, USA), Euxyl K400, and fragrance mix I because of the frequent use of moist (baby) wipes during the pandemic outbreak.

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Berotralstat for the Prophylaxis of Hereditary Angioedema: Outcomes in a Large Regional Immunology Centre in the UK

Hereditary angioedema (HAE) is a rare and potentially life-threatening genetic condition, whereby patients present with recurrent episodes of swelling. This affects the subcutaneous and submucosal tissues of the skin as well as mucous membranes such as the respiratory and gastrointestinal tracts.

Huntingtin as a Presymptomatic Regulator of Alzheimer’s Disease

The identification of pathological elements that drive disease progression, so-called regulators, is essential when studying progressive diseases.

Updates in the Treatment of Gastroenterological Disorders

Digestive Disease Week (DDW) 2022 was held both in San Diego, California, USA, and virtually. The meeting featured cutting-edge research and education in the field of gastroenterology, of which eight treatment-related presentations are summarised in this article.

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Review of the European Academy of Neurology (EAN) 2022 Congress

THE CURTAIN OPENED on the 8th European Academy of Neurology (EAN) 2022 Congress on 25th June 2022 in Vienna, Austria, with EAN President Claudio Bassetti welcoming more than 8,000 neurologists from around the world.

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Implications of the First Ex Vivo Gene Therapy Approved for Treating Early-Onset Metachromatic Leukodystrophy

MLD is caused by an accumulation of sulfatides in various organs and predominantly the central nervous system (CNS). Patients have an initial period of normal development, then experience developmental delay or stagnation (Figure 1).