Uncategorised - European Medical Journal

Field Cancerisation of the Upper Aerodigestive Tract: Screening for Second Primary Cancers of the Oesophagus in Cancer Survivors

Tobacco, alcohol, and betel quid are the main causes of squamous cell cancers of the upper aerodigestive tract. These substances can cause multifocal…

Perspectives in Surgery of Oligometastatic Non-Small-Cell Lung Cancer

20-50% of patients with newly diagnosed non-small-cell lung cancer (NSCLC) have synchronous metastases. This dramatically affects survival and…

Symptoms and Quality of Life in Gastroenteropancreatic Neuroendocrine Tumours

Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) have the ability to induce symptoms either by their direct mass effect on local tissues…

Recent Advances in Definitive Radiotherapy for Prostate Cancer

Definitive radiation therapy is a well-recognised curative treatment option for localised prostate cancer. A suitable technique, dose, target volume…

Development of Drugs Targeting the PI3K Signalling Pathway in Leukaemias and Lymphomas

The phosphoinositide 3-kinase (PI3K) family of signalling enzymes play a key role in the transduction of signals from activated cell surface receptors…

Alloimmune Thrombocytopaenic Disorders: A Review

Alloimmune thrombocytopaenia (AIT) is caused by alloantibodies against specific platelet glycoproteins. Alloimmune thrombocytopaenic disorders include…

Multiple Myeloma and Renal Failure

Renal failure (RF) occurs in approximately 20-30% of multiple myeloma (MM) patients at diagnosis and in more than 50% of patients with advanced disease.

Checkpoint Blockade in Cancer Immunotherapy: Squaring the Circle

Manipulating the complex interaction between the immune system and tumour cells has been the focus of cancer research for many years, but it is only in…

How I Treat: Prognostication in Chronic Lymphocytic Leukaemia: A Gaze into the Future

Chronic lymphocytic leukaemia (CLL) is due to the relentless accumulation of monoclonal B lymphocytes with a distinct immunophenotype…

EMJ

ESMO 2014: The collaboration between UCL and the Francis Crick Institute

At ESMO 2014, Prof Jonathan Ledermann (UCL, UK) discusses the collaboration between UCL and the Francis Crick Institute that is hoped to increase the…