Uncategorised - European Medical Journal

EMJ

Towards a Standardised Method to Acquire and Store Liver Samples and Guidelines to Improve Quality Control and Exchange of Relative Expression Data

The current ‘state-of-the-art’ molecular techniques are extremely sensitive and consequently prone to false results. Even more so than in the past…

EMJ

Viral Proteins Mediate Upregulation of Negative Regulatory Factors Causing Down-Modulated Dendritic Cell Functions In Chronic Hepatitis C Virus Infection

Stunted cellular immune response against a narrow range of epitopes is the hallmark of chronic hepatitis C infection, but the underneath molecular…

EMJ

Management of Hepatitis B Virus Infection in Liver Transplant Recipients

Hepatitis B virus (HBV)-related liver disease is a common indication for liver transplantation (LT) in Asian countries. When left untreated, the overall…

EMJ

IL28B Polymorphisms in Interferon-Treated Patients with Chronic Hepatitis B

Pegylated interferon (Peg-IFN) may achieve a sustained off-treatment response in 20-30% of the patients with chronic hepatitis B (CHB).

EMJ

Cellular Consequences of Z Alpha-1 Antitrypsin Accumulation and Prospects for Therapy

The Z variant (Glu342Lys) of α1-antitrypsin polymerises and accumulates in the hepatocyte endoplasmic reticulum predisposing to neonatal hepatitis…

EMJ

Acute-On-Chronic Liver Failure: Applying the PIRO Concept

Acute-on-chronic liver failure (ACLF), a clinical syndrome associated with a dismal prognosis, occurs acutely in previously stable cirrhotic patients.

EMJ

Adrenal Insufficiency (AI) in Cirrhosis

Adrenal dysfunction or insufficiency (AI) in cirrhosis, also described as hepato-adrenal syndrome, is an only recently recognised entity.

EMJ

Hepatic Encephalopathy: A Paradigm Shift

The most recent understanding of the pathogenesis of hepatic encephalopathy (HE) is that heterogeneous precipitating factors cause a low-grade cerebral…

Treatment of Hepatic Encephalopathy – Targeting the Gut-Liver-Brain Axis

Summary of Presentations from the Norgine Sponsored Satellite Symposium, UEG Week, Berlin, Germany, 12th–16th October 2013

State-of-the-Art Treatment of Irritable Bowel Syndrome – Recent Advances and Emerging Therapeutic Alternatives

Irritable bowel syndrome (IBS) is a highly prevalent functional disorder characterised by chronic and recurrent abdominal pain and altered bowel habit.