Abstract
Atrial fibrillation (AF) associated with familial hyperthyroidism (FH) spanning three generations concomitantly, is rare. The index case was 10 years old when he started having AF secondary to hyperthyroidism, and is the youngest case documented. His mother was diagnosed at 31 years of age, 8 years after giving birth to him; and his maternal grandmother was diagnosed with the same goitre problem, hyperthyriodism, and palpitations at 49 years of age. The index case also has a restrictive perimembranous ventricular septal defect, which makes it a clinically challenging and more interesting case.
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