NICE has officially recommended 12 SQ-HDM SLIT, for treating persistent moderate to severe house dust mite allergic rhinitis in individuals aged 12–65. This marks a significant milestone as the first treatment of its kind to receive approval from NICE.
An estimated 13,000 people in England stand to benefit from this new therapy. For those whose allergic rhinitis remains uncontrolled despite standard treatments such as antihistamines and steroid nasal sprays, this drug presents a much-needed alternative that could significantly enhance their quality of life.
Allergic rhinitis caused by house dust mites can be a chronic and debilitating condition, severely impacting daily activities, work, and education. Symptoms include sneezing, nasal congestion, an itchy or runny nose, and red, watery eyes. In more severe cases, it can lead to facial swelling, fatigue, and disrupted sleep. Persistent allergic rhinitis is defined by symptoms occurring for at least four days a week for over a month, without relief from conventional treatments.
The newly recommended immunotherapy works by gradually increasing the body’s resistance to house dust mites. It involves the daily administration of a fixed amount of house dust mite allergy extract over a three-year period, helping the immune system develop tolerance and reducing allergic reactions over time. Clinical trials have demonstrated its efficacy, particularly in individuals who have not found relief through standard medications.
The recommendation has been welcomed by allergy experts and patient advocates. The ability to access this treatment through the NHS provides a much-needed option for those who have long struggled with persistent symptoms. While an initial specialist consultation is required, the treatment can largely be self-administered at home, reducing the need for frequent hospital visits and associated costs.
By offering a cost-effective and accessible solution, this development represents a crucial step forward in the management of allergic rhinitis. With its potential to alleviate symptoms and improve overall well-being, this treatment offers new hope for thousands of individuals living with the condition.
Katie Wright, EMJ
Reference
National Institute for Health and Care Excellence. Thousands of people with a severe dust mite allergy are set to benefit from life-changing treatment. Available at: https://www.nice.org.uk/news/articles/nice-recommends-innovative-life-changing-treatment-for-people-with-a-severe-dust-mite-allergy. Last accessed: 3 February 2025.
