A NEW study has found that individuals with systemic lupus erythematosus (SLE) face a significantly increased risk of cervical artery dissection (CeAD), a rare but potentially life-threatening condition. Published in Scientific Reports, the study highlights the importance of vigilant cardiovascular monitoring in patients with lupus.
Researchers analysed de-identified electronic medical records from 2012 to 2020, comparing two matched cohorts of 77,008 patients each: those with SLE and those without. Using propensity matching to control for confounding factors, the study revealed that the risk of CeAD was more than doubled in the SLE group compared to non-lupus controls (0.08% vs. 0.04%; RR = 2.33, p < 0.0001). The majority of participants were female (89%), reflecting the typical demographic of lupus patients.
CeAD, which involves a tear in the wall of a cervical artery, can lead to severe complications such as stroke. This study’s findings confirm earlier suggestions of an association between autoimmune diseases like lupus and increased vascular risk, although the underlying mechanisms remain unclear.
“These results underscore the need for heightened awareness and early detection of cardiovascular complications in patients with lupus,” the researchers stated.
The authors call for further research to explore the mechanisms linking SLE to CeAD and to investigate whether similar risks exist for other autoimmune conditions. With early detection and management, healthcare providers can mitigate potential complications and improve outcomes for patients with lupus.
Aleksandra Zurowska, EMJ
Reference
Trager RJ et al. Systemic lupus erythematosus is associated with an increased risk of cervical artery dissection. Sci Rep. 2025;DOI: 10.1038/s41598-025-85655-2.
