Phase 3 CheckMate 067 trial of nivolumab in untreated advanced melanoma

Hendrik-Tobias Arkenau, MD, PhD, of Sarah Cannon Research Institute, UK, disusses the results of the CheckMate 067 trial, a phase 3 trial of nivolumab (NIVO) alone or combined with ipilimumab (IPI) versus IPI alone in treatment-naïve patients with advanced melanoma. NIVO combined with IPI and NIVO alone had superior clinical activity versus IPI alone. The results with NIVO combined with IPI and NIVO alone further suggest complementary activity of the two agents. There were no new safety signals or drug-related deaths observed with the combination.

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