Multiplex Urinary Tests for Bladder Cancer Diagnosis

Virginia Urquidi,1 Charles J. Rosser,2 Steve Goodison3

1. Associate Professor, Cancer Research Institute, MD Anderson Cancer Center, University of Central Florida College of Medicine, USA
2. Professor, Department of Urology, University of Central Florida College of Medicine, USA
3. Professor, Cancer Research Institute, MD Anderson Cancer Center, University of Central Florida College of Medicine, USA

Disclosure: The authors are affiliated with Nonagen Bioscience Corporation.
Citation: EMJ – Urology, 2013: 1, 70-73

Abstract

The development of accurate and reliable molecular assays that could diagnose bladder cancer would be of significant benefit to both patients and the healthcare system. Non-invasive assays that have utility not only for diagnosis, but also for monitoring disease recurrence and response to treatment, are needed. Current urinary tests lack sufficient sensitivity or specificity, often because of a reliance on single biomarkers, but high-throughput technologies are enabling the derivation of more accurate panels of biomarkers. In this article, we review some of the promising investigational studies that are revealing multiplex biomarker signatures that may augment current bladder cancer detection strategies.

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