Role of Nuclear Receptors in Spontaneous and Recurrent Miscarriage

*Julia Knabl,1 Aurelia Vattai,1 Brigitte Ziegelmüller,2 Nina Ditsch,1 Udo Jeschke1

1. Department of Obstetrics and Gynecology, Ludwig Maximilian University of Munich, Munich, Germany
2. Department of Urology, Ludwig Maximilian University of Munich, Munich, Germany
*Correspondence to julia.knabl@med.uni-muenchen.de

Disclosure: The authors have declared no conflicts of interest.
Received: 26.01.15 Accepted: 21.04.15
Citation: EMJ Repro Health. 2015;1[1]:95-100.

Abstract

Although early pregnancy loss is a common complication of human reproduction, a significant proportion of miscarriages still happen for unknown reasons. Nuclear receptors are key players in trophoblast invasion and metabolism; therefore, their agonists and ligands are a promising target for the prevention of miscarriage. This review gives an overview of the existing data and literature concerning the involvement of nuclear receptors in maintaining a viable pregnancy.

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