State-of-the-Art Integration of Multiple Kinase Inhibitors in the Treatment of Gastrointestinal Cancers

This satellite symposium took place on 4th September 2016 as a part of the European Society of Medical Oncology (ESMO) Congress in Copenhagen, Denmark

Chairperson: Axel Grothey1
Speakers: Marc Ychou,2 Jean-Yves Blay,3 Eric Van Cutsem,4 Jordi Bruix5

1. Mayo Clinic, Rochester, Minnesota, USA
2. Montpellier Cancer Institute, Montpellier, France
3. Medical Oncology Department, Centre Léon Bérard, Lyon, France
4. University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
5. BCLC Group, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain

Disclosure: Prof Grothey has received honoraria and grants, paid to the Mayo Foundation, from Amgen, Bayer, Boehringer Ingelheim, Boston Biomedicals, Genentech, and Taiho. Prof Ychou has received research support and honoraria from Bayer, Roche, Celgene, Baxalta, and Lilly. Prof Blay has received research support and honoraria from Bayer, Novartis, Pfizer, and Roche. Prof Van Cutsem has received a research grant from Bayer. Dr Bruix has received consultancy fees from AbbVie, Argule, Bayer, BMS, Boehringer Ingelheim, BTG, Eisai, Gilead, Kowa, Novartis, Onxeo, OSI, Roche, Sirtex, and Terumo, and has received research grants from Bayer.
Acknowledgements: Writing assistance was provided by Dr Blair Hesp, CMPP, ApotheCom, London, UK. Support: The symposium was sponsored by Bayer. Authors received honoraria for preparation and delivery of their presentations. The views and opinions expressed are those of the authors and not necessarily of Bayer.
Citation: EMJ Oncol. 2016;4[1]:38-46.

Meeting Summary

This symposium provided an overview of the efficacy and safety of multikinase inhibitors in colorectal cancer, including treatment sequencing, followed by an examination of the evidence in support of combination therapies and the use of regorafenib in gastrointestinal stromal tumours (GISTs) and other sarcomas. Prof Axel Grothey opened the symposium by introducing multikinase inhibitors and their role in treating malignancies. Prof Marc Ychou reviewed the Phase III studies supporting the use of regorafenib in later lines of therapy for patients with metastatic colorectal cancer (mCRC). Prof Grothey then discussed practical considerations when treating patients with regorafenib, including treatment sequencing and management of adverse events (AEs). Prof Jean-Yves Blay reviewed the efficacy and safety of regorafenib in treating GISTs and other sarcomas. Prof Eric Van Cutsem discussed potential future roles for regorafenib in treating difficult-to-treat malignancies such as advanced gastric and oesophagogastric cancer. Dr Jordi Bruix then demonstrated the possibility of using regorafenib as a second-line therapy in patients with hepatocellular carcinoma (HCC) who have progressed following sorafenib therapy.

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