Recent Advances in Definitive Radiotherapy for Prostate Cancer

*Michael Pinkawa

Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
*Correspondence to MPinkawa@ukaachen.de

Disclosure: No potential conflict of interest.
Received: 27.10.14 Accepted: 17.12.14
Citation: EMJ Oncol. 2015;3[1]:41-48.

Abstract

Definitive radiation therapy is a well-recognised curative treatment option for localised prostate cancer. A suitable technique, dose, target volume, and the option of a combination with androgen deprivation therapy needs to be considered. An optimal standard external beam radiotherapy includes currently the intensity-modulated and image-guided radiotherapy techniques with total doses of ≥76-78 Gy in conventional fractionation. Data from several randomised studies increasingly support the rationale for hypofractionated radiotherapy. A simultaneous integrated boost with dose escalation focused on a computed tomography/positron emission tomography or magnetic resonance imaging/magnetic resonance spectroscopy detected malignant lesion is an option to increase tumour control with potentially no additional toxicity. The application of a spacer is a promising concept for optimal protection of the rectal wall.

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