Prostate cancer and inflammation: The role of miRNAs

Sabina Davidsson, Jessica Carlsson

Department of Urology, Örebro University Hospital, Örebro, Sweden, and School of Health and Medical Sciences, Örebro University, Sweden. Members of the Trans-disciplinary Prostate Cancer Partnership (ToPCaP)

Disclosure: No potential conflict of interest.
Received: 26.08.13 Accepted: 28.10.13
Citation: EMJ Oncol. 2013;1:56-60.

Abstract

Approximately 15-20% of all human cancers are assumed to be a result of infection and chronic inflammation due to a constant supply of cytokines and reactive oxygen species, giving rise to genomic instability and a subsequent tumour development. In recent years, chronic inflammation has also been hypothesised to influence prostate carcinogenesis, since both acute and chronic inflammation is commonly seen in prostatic tissues. The signalling pathways involved in the immune response and tumor development are overlapping with each other, and it has been proposed that miRNAs are a possible link between the two processes. In this review, we are describing some of the miRNAs which could constitute a conceivable link between inflammation and prostate cancer.

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