Cabozantinib as First-Line Therapy for Patients with Metastatic Renal Cell Carcinoma with Poor or Intermediate-Risk Characteristics

This Presidential Symposium took place on 10th October 2016 as a part of the European Society for Medical Oncology (ESMO) Congress in Copenhagen, Denmark

Speaker: Toni K. Choueiri

Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Disclosure: Associate Prof Choueiri has received honoraria for advisory board membership and consultancy from Pfizer, Exelixis, Novartis, Merck, BMS, Bayer, Roche, Prometheus, Calithera, Peloton, and Foundation Medicine. His institution has received research funding from Exelixis, Pfizer, Novartis, BMS, Merck, Roche, Tracon, and Peloton.
Acknowledgements: Writing assistance was provided by Dr Blair Hesp, CMPP, of ApotheCom.
Support: The author has received a research grant from Exelixis to support this review. The views and opinions expressed are those of the authors and not necessarily of Exelixis.
Citation: EMJ Oncol. 2016;4[1]:56-59.

Meeting Summary

The oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI) sunitinib is a standard first-line therapy for patients with metastatic renal cell carcinoma (mRCC).1 Survival outcomes for patients with mRCC treated with sunitinib vary between prognostic risk groups, defined by the International mRCC Database Consortium (IMDC) criteria.2,3 For example, median progression-free survival (PFS) is expected to be lower in patients with poor or intermediate-risk characteristics compared with the overall patient population, with one study reporting PFS of 5.6 months following first-line targeted therapy in patients with poor or immediate-risk characteristics compared with 7.2 months for the overall population.4 Furthermore, the presence of bone metastases is also associated with less favourable outcomes in patients with mRCC.5

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