Alloimmune Thrombocytopaenic Disorders: A Review

*Sophia Delicou, Marianna Bellia

Thalassemia and Transfusion Unit, Hippokrateion General Hospital of Athens, Athens, Greece
*Correspondence to sophiadelicou@gmail.com

Disclosure: Both authors declare no support from any organisation for the submitted work; no financial relationships in the previous 3 years with any organisations that might have an interest in the submitted work; and no other relationships or activities that could appear to have influenced the submitted work.
Received: 27.12.14 Accepted: 29.01.15
Citation: EMJ Oncol. 2015;3[1]:59-64.

Abstract

Alloimmune thrombocytopaenia (AIT) is caused by alloantibodies against specific platelet glycoproteins. Alloimmune thrombocytopaenic disorders include alloimmune neonatal thrombocytopaenia, posttransfusion purpura, refractoriness to platelet transfusions, passive AIT, and transplantation-associated AIT. In this review we have summarised five thrombocytopaenic syndromes caused by platelet-reactive alloantibodies. Increased awareness of these syndromes, together with the greater availability of highly specialised laboratory methods to detect and to characterise platelet-reactive alloantibodies, will lead to their more frequent diagnosis.

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