Understanding Exercise-Associated Hyponatraemia: From Pathophysiology to Treatment

*Sidonie Hubert,1 Cédric Bruel,2 François Philippart2

1. Internal medicine, Groupe hospitalier Paris Saint Joseph, Paris, France
2. Intensive care unit, Groupe hospitalier Paris Saint Joseph, Paris, France
*Correspondence to shubert@hpsj.fr

Disclosure: The author declares no potential conflict of interest.


The practice of extreme sports is becoming more and more common. Despite physiological adaptation, people who intensively exercise are exposed to exercise-associated complications, including hyponatraemia. Exercise-associated hyponatraemia seems to be a consequence of alteration of water regulation, particularly by excessive expression of vasopressin, sodium mobilisation, and interleukin-6 production by muscular cells. Preventing overhydration, both before and during effort, and prohibiting hypotonic solutes during treatment are the leading interventions to correct hyponatraemia.

Download (PDF, 101KB)

Comments are closed.