Understanding Exercise-Associated Hyponatraemia: From Pathophysiology to Treatment

*Sidonie Hubert,1 Cédric Bruel,2 François Philippart2

1. Internal medicine, Groupe hospitalier Paris Saint Joseph, Paris, France
2. Intensive care unit, Groupe hospitalier Paris Saint Joseph, Paris, France
*Correspondence to shubert@hpsj.fr

Disclosure: The author declares no potential conflict of interest.

Abstract

The practice of extreme sports is becoming more and more common. Despite physiological adaptation, people who intensively exercise are exposed to exercise-associated complications, including hyponatraemia. Exercise-associated hyponatraemia seems to be a consequence of alteration of water regulation, particularly by excessive expression of vasopressin, sodium mobilisation, and interleukin-6 production by muscular cells. Preventing overhydration, both before and during effort, and prohibiting hypotonic solutes during treatment are the leading interventions to correct hyponatraemia.

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