How I Diagnose Hypereosinophilic Syndromes

*Simon Kavanagh, Jeffrey H. Lipton

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada
*Correspondence to

Disclosure: The authors have declared no conflicts of interest.
Received: 21.02.17 Accepted: 07.08.17
Citation: EMJ. 2017;2[3]:15-20.


Hypereosinophilic syndromes are a group of disorders characterised by significant eosinophilia and organ damage. They have proven challenging to define, diagnose, and study for many years, due in part to their variable clinical presentations, the overlap between neoplastic and reactive eosinophilia, and the lack of a universal marker of eosinophil clonality. Herein, we give an overview of the term and discuss aetiology and our approach to diagnosis.

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