Treatment of Advanced Cholangiocarcinoma: Current Status and Future Perspectives

Jan B. Kuhlmann

Citation: EMJ Gastroenterol. 2012:1:63-67.


Cholangiocarcinoma (CC) is a tumour with a poor prognosis. The treatment of CC is challenging as the tumour is usually diagnosed late and the treatments are not very effective except when complete surgical resection is possible. However in the majority of cases, surgical resection is not possible and palliation is the mainstay of treatment. Currently chemotherapy combining gemcitabine with a platinum agent is the recommended first- line treatment regimen for advanced CC. Since, CCs have only a limited tendency to metastasize locoregional therapy is an interesting approach.

The aim of this short review is to give an update on standard and prospective treatment concepts in advanced cholangiocarcinoma based on a comprehensive review of the recent literature and guidelines.

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