Endoscopic Optical Enhancement Technologies in IBD

Gian Eugenio Tontini,1,2 Maurizio Vecchi,2,3 Markus F. Neurath,1 Helmut Neumann1

1. Department of Medicine I, University of Erlangen-Nuremberg, Germany
2. Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy
3. Department of Biomedical Science for Health, University of Milan, Italy

Disclosure: No potential conflict of interest.
Received: 14.10.13 Accepted: 20.11.13
Citation: EMJ Gastroenterol. 2013;1:54-61.


Optical enhancement technologies are emerging as promising tools to improve diagnosis and clinical management of patients with inflammatory bowel diseases (IBD). The use of dye-based and dye-less chromoendoscopy may improve either characterisation of mucosal inflammation or detection of dysplastic and early neoplastic lesions. Confocal laser endomicroscopy and endocytoscopy both allow for in vivo and real-time microscopic analysis of the tissue. Moreover, the newly introduced molecular imaging has now also become feasible for in vivo diagnosis in IBD. This review focuses on the more recent progresses of advanced endoscopic imaging techniques in the setting of IBD and provides the reader with an updated overview on accepted clinical evidence and ongoing fields of research.

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