The Skin Microbiome in Patients with Acne Vulgaris

This symposium took place on 9th October 2015,  as part of the European Academy of Dermatology and  Venereology Congress in Copenhagen, Denmark

Co-Chairs: Brigitte Dréno,1 Thomas Bieber2
Speakers: Thomas Bieber,2 Brigitte Dréno,1 Sophie Seité3

1. Nantes University, Nantes, France
2. University of Bonn, Bonn, Germany
3. La Roche-Posay Dermatological Laboratories, Asnières, France

Disclosure: Thomas Bieber has received sponsorship from La Roche-Posay, Galderma, Bioderma, Novartis, Regeneron, Pfizer, Celgene, Anacor, and Chugai. Brigitte Dréno has received sponsorship from  Galderma, Meda, La Roche-Posay, Fabre, Bioderma, GSK, Roche, and BMS. Sophie Seité is an employee of La Roche-Posay Dermatological Laboratories (Asnières, France).
Acknowledgements: Writing assistance was provided by Dr Juliane Moloney, ApotheCom.
Support: The publication of this article was funded by La Roche-Posay Dermatological Laboratories. The views and opinions expressed are those of the authors and not necessarily of La Roche-Posay  Dermatological Laboratories.
Citation: EMJ Dermatol. 2015;3[1]:45-50.

Meeting Summary

Similar to some other tissues such as the gut, the skin is colonised by a dense community of commensal microorganisms. Maintaining the balance of this diverse flora may be important for healthy skin. Changes in the composition of cutaneous microbial communities have been linked to several chronic inflammatory  skin diseases, including atopic dermatitis, psoriasis, and acne. Acne is a chronic inflammatory disease that affects the pilosebaceous follicle. The association between Propionibacterium acnes and acne vulgaris has been well established, but very few studies have investigated the total facial skin microbiota of acneaffected patients. Three-dimensional topographic analyses and microbiome profiling have, however, revealed differences in microbiome composition between healthy skin and acne lesions, as well as natural differences in microbial colonisation between the sebaceous gland and surface skin.1 Furthermore, bacterial communities of the skin are involved in immune homeostasis and inflammatory responses important in  the development of all acne lesions.2 This improved understanding of the interactions between skin microbiota and the innate immune response in acne may provide a platform to design efficacious treatment strategies, specifically concerning the role of dermocosmetics to protect the skin microbiome.

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