Proteomic Analysis of Antiprotease Immunoglobulin-E Anti-Sperm Autoantibodies in Chronic Urticaria After Vasectomy

*David H. Dreyfus

Yale School of Medicine, Yale University, New Haven; Gesher LLC, Allergy Asthma and Clinical Immunology, Waterbury, Connecticut, USA
*Correspondence to dhdreyfusmd@gmail.com

Disclosure: The author has declared no conflicts of interest.
Acknowledgements: The author acknowledges the assistance of Dr Silvia Pulido and Dr Alina Domagala in the laboratory of Dr John C. Herr for performing proteomic studies and also helpful information on the biology and immunology of sperm proteins. Dr Herr’s laboratory was supported by National Institutes of Health Grant HD U5429099, D43 TW/HD 00654 from the Fogarty International Center and Schering AG. The author also acknowledges helpful discussions with Dr Marcus Maurer, Charite Hospital, Berlin, Germany. The serum 203c basophil activation assay was performed by Dr. Ronald Harbeck, National Jewish Medical and Research Center (NJMRC), Denver, Colorado, USA. HLA-type antigens associated with other dermatologic syndromes were screened for and obtained from Quest Diagnostics, Teterboro, New Jersey, USA.
Received: 24.05.17 Accepted: 20.09.17
Citation: EMJ. 2017;2[4]:106-113.

Abstract

Some types of chronic urticaria (CU) are associated with autoreactive immunoglobulin (Ig)E, as well as IgG. In the syndrome of autoimmune thyroid disease and CU, autoreactive IgE, as well as IgG against host thyroid tissue, is present. The author describes a patient with new onset of CU after vasectomy with evidence of both autoreactive IgE and IgG anti-sperm antibodies (ASA). Autoreactive sperm proteins are enzymes opposed to structural sperm antigens producing ASA in infertility and after anti-spermatocyte vaccines. The author suggests that autoreactive proteins with enzymatic activity either in host proteins, aeroallergens, or viral proteins may have increased propensity to generate autoreactive IgE. This model of autoimmune IgE ASA generation by sperm and other host enzymatic proteins in CU can be tested using proteomic technology.

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